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Reversal of Diabetes in the Ketogenic Zone – A Case Report

Low Carb ZoneThis week I had the pleasure of seeing a really nice 46 year old Hispanic male who is fairly new to the office.  He came back in to see me in follow up on his diabetes.  To give you a bit of background history, the patient came to see me about 6 months ago, just not feeling very well. Based on his symptoms of fatigue, history of elevated blood sugar and family history, lab work was completed.He saw us initially with a Hemoglobin A1c of 12.3% in June (normal should be 4.9%-5.6%).  This means he had an average blood sugar over the previous three months of about 310 mg/dL (normal should be < 110 mg/dL).

Past Medical History include:  Diabetes Mellitus – type II (not on any medications when initially seen), Hypertension (high blood pressure), Dyslipidemia (elevated cholesterol) and a non-specific heart arrhythmia.

Medications: None

Surgeries: Knee & shoulder arthroscopies

Family History: Father Diabetes, Stroke, Heart Disease, Hypertension, Elevated Cholesterol

Social History: Non-Smoker, Limited Alcohol Use

He related to me that he had been on metformin before, however, had some significant diarrhea and was not interested in using this medication EVER again.   A previous doctor had tried Victoza© (liraglutide), a GLP-1 inhibitor, but he didn’t use it for very long as he didn’t really see much change with this medication.

After getting his labs back, we had a very long conversation about the need to either fix his diet dramatically, or he may be looking at using 3-4 oral medications or even insulin to control his blood sugar.

When I see average blood sugars (HbA1c) stay over 6.5%  (or greater than 140 mg/dL), the risk for retinal, kidney and nerve damage is significant and often irreversible after 4-5 years.  Most physican’s are affraid to lower the HbA1c to less than 7.0% with medications due to low blood sugar events, and so the diabetes community has “settled” with 7.0% as being effective.  However, it still isn’t low enough.  I saw this happen with my father and with other members of me family.  I’ve seen it happen over and over with my patients over the last 15 years when they have not lowered their blood sugar and reduced the high insulin loads that occur in response to those high blood sugar levels.  It has been my experience that HbA1c can be very safely lowered to the normal range, as low as 5.2-5.6% without symptomatic low blood sugars, with the correct diet and careful use of medications.

So, my patient, above, committed to change.  I was worried that diet alone would not be able to lower these levels enough to be effective so we discussed tight carbohydrate restriction, the addition of methlyated folate and chromium and a re-trial of a low dose of Victoza© (liraglutide), which he had at home.

I didn’t see him for about three months.  When he followed up this week I was amazed.  I was amazed because I rarely see more than 1.5% drop in HbA1c with the addition of Victoza© (liraglutide).  The additional 4.5% of drop with diet was dramatically impressive.

When we talked, he told me that all he has done differently is use the Victoza© (liraglutide) and cut his carbohydrate intake to less than 10 grams per meal (Yes, he did admit to occasionally cheating).

You can see the dramatic results:

June 2015
September 2015
Glucose
258
103
HbA1c
12.3%
6.3%
Urine Creatinine (Random)
208
72
 
Total Cholesterol (mg/dL)
219
218
Triglycerides (mg/dL)
137
117
HDL-C (mg/dL)
38
37
LDL-C (mg/dL)
154
158
LDL-P (nmol/L)
2172
1691
Small dense LDL-P (nmol/L)
1289
419
 
TSH (mU/L)
1.75
 

As you can see, a dramatic change in his blood sugar has occurred in a three month interval.  Not only that, we see a significant change in his cholesterol profile.

Some might argue that this is the Victoza© (liraglutide) doing this.  I can tell you, in the 15 years I’ve been doing this and in the 5 years that Victoza© (liraglutide) has been available in the U.S., I have never seen a drug reduce blood sugar or cholesterol this dramatically.

Cholesterol SizePreviously, we looked at LDL-C for heart disease risk, however, I have multiple patients that have had heart disease with normal LDL-C ( <100 mg/dL).  LDL-C is just a summation of all the particles. The LDL particle is actually made up of three sub-types and it is specifically the small dense particle that causes the vascular risk. You can see a dramatic normalization of the small dense particle LDL with no change in LDL-C and minimal change in Total Cholesterol in the patient’s labs when he reduces his carbohydrate intake.  This is a pattern I see every single day. When serial carotid ultrasound studies are completed, I see reduction in blockage and reduction in the vascular wall thickening.   I will be very interested to see the vascular studies on this patient and I will await his results as he tightens up his diet even further.

All in all, he has dramatically brought his diabetes under control with carbohydrate restriction and if he continues this lifestyle, he has reduced his risk for retinal damage, reduced his risk for kidney damage, reduced his risk for nerve damage and essentially added 20 years to his life.

(Disclosures:  Dr. Nally has no vested interest, monitary or otherwise, in Novo Nordisc or it’s products including liraglutide.)

Psychology of the Ketogenic Lifestyle . . .

Ketogenic Lifestyle – the Balance of Endocrinology & Psychology

Over the last few weeks, I’ve had the pleasure of talking to a number of patients and friends about what it means to live a ketogenic lifestyle.  A low-carbohydrate or ketogenic lifestyle is different from a low-carb diet. It is different because the definition of lifestyle implies the way a person lives their life that reflects specific attitudes and values, not just how they eat. My recent posts, The Principle Based Ketogenic Lifestyle – Part I and Ketogenic Principles – Part II, focus on fundamental principles making the ketogenic lifestyle one in which balance and grounding in all aspects of life can occur.  When the mind, the body or the spirit are out of balance or un-grounded, symptoms of metabolic inefficiency, sickness or disease result. 

I have been fascinated, as a family practitioner, that the body produces “warning flags,” when there is dysfunction in one of these areas: mind, body & spirit. These warning flags are byproducts of inefficient inter-related functionality between the body’s systems and it is one of the foundation principles of osteopathic medicine.  Prior to the advent of many of our diagnostic techniques today like MRI, CT scan, advanced laboratory evaluations, and ultrasound, these were the only indicators of disease that a physician could identify, and upon which diagnosis was made. These flags often show up on the skin, in the hair or nails, in the complexion, or in general appearance or mannerisms.

Skin tags
Skin Tags (fibroepitheial polyps) under the arm

For example,”skin tags” are now recognized as pathognomonic, specifically indicative, of insulin resistance and will often occur up to 20 years before impaired fasting glucose or diabetes is ever recognized.

exopthalmos 2
Exopthalmos (bulging or protruding of the eyes) from hyperthyroidism

Exopthalmos, or protrusion of the eyes, is pathognomonnic for overactive thyroid function (hyperthyroidism), and spider angiomas occur as a somatic flag that cirrhosis of the liver is present.

Alligator Skin (severe dry skin) found in hypothyroidism
Alligator Skin (severe dry skin) found in hypothyroidism

Hair loss and dry skin, or “alligator skin,” represents the exact opposite with an under-active thyroid (hypothyroidism).

spider-angioma
Spider angioma seen with cirrhosis

When metabolic pathways get “clogged” or flow of blood, lymphatic fluid or hormones do not reach the destinations they were meant to reach, symptoms of accumulation or poor function begin to arise.

Anterior Chapman's Reflex Points
Anterior Chapman’s Reflex Points (images adapted from Osteopathic Foundations of Medicine.)

The osteopath is also trained to recognize a corollary Chapman’s Reflex Points that act as flags for dysfunction in specific organs or regions of the body. These points relate directly to what causes the pathognomonic flag.  I frequently identify abdominal, adrenal, pancreatic and liver Chapman’s points present in those with insulin resistance, inflammatory diseases, pre-diabetes and diabetes.  Understanding how to interpret and use these flags comprises four years of medical school and three to four years of residency and often years of clinical application.

Mental or spiritual pathways can often be bloc-aided by poor recognition of, or refusal to acknowledge, individual truths in our lives. Interestingly, the signs or warning flags of spiritual dysfunction are also expressed physically.

“Oh, no?! Dr. Nally are you going to get all religious on us?”

Maybe.

Over the last 15 years of my medical practice, I’ve witnessed the spiritual component of the “mind, body, spirit” unit, or lack thereof, have profound impact on the body’s ability to heal.  Every one of us must defeat what Sigmund Freud called the pleasure principle – the human instinct to seek pleasure and avoid pain, including recollections or memories that are painful.    Hiding from these memories because of pain is very common and is part of human nature.  We often believe that thinking about or re-living the truth may cause us individual overwhelming un-survivable grief.  So, we naturally bury the thoughts and emotions and feelings deep down into our subconscious minds.

In fact, we take irrational risks, busy ourselves, use food or drink for short term comfort and move from one distracting or debilitating relationship to another. We lose and then regain gain weight, become workaholics, hide behind thousands of texts, social media posts and emails in order to protect ourselves from the part of ourselves that we don’t want to think about.

However, when we step away from the distractions and courageously look at our individual history, our personal life story, honestly and completely, feelings of sadness, anxiety, regret and anger may often arise.  These painful emotions bring with them essential insights into how experiences will help you and I individually grow, become a better people, and help others along the path.  It takes faith to trust that these experiences will not destroy us, but were allowed to occur by a loving Father or Creator, understanding that for you and I to grow, we must each be given individual agency to chose.  It takes faith to recognize that that Father has your individual best interest in mind. Hiding from these emotions clogs the mental and spiritual systems and fuels disabling depression, anxiety, insomnia and fatigue. These feelings, real as they are, persist when there is no other physical sign of illness.  That’s because this illness is not physical.  It is spiritual. When we are out of line with the truths that bring peace and balance to our lives, negative, self-limiting patterns of activity and fear stifle growth and development mentally.

It is fascinating to me that on more than one occasion, as an osteopath, when a patient suffering from these symptoms gets a massage or has an osteopathic or chiropractic manipulative treatment, they may suddenly become tearful or have unexpected release of emotion. Physical treatment over the areas of congestion can, and do, cause a reflex triggering of mental, emotional or spiritual release of tensions.

How do I know that it is truth we are hiding from?  Take the words of the Buddhist teacher Sogyal Rinpoche found in The Tibetan Book of Living and Dying among many others throughout the ages:

“Saints and mystics throughout history have adorned their realizations with different names and given them different faces and interpretations, but what they are all fundamentally experiencing is the essential nature of the mind.  Christians and Jews call it “God”; Hindus call it “the Self,” “Shiva,” “Brahman,” and “Vishnu”; Sufi mystics name it “the Hidden Essence”; and the Buddhists call it “buddha nature.” At the heart of all religions is the certainty that there is a fundamental truth, and that this life is a sacred opportunity to evolve and realize that truth.”

Wait a minute, what does all this have to do with a ketogenic lifestyle?

The ketogenic lifestyle is one that is based on values.  A patient following a ketogenic diet recognizes that food has just as powerful effect on the hormones of the body as does prescription drugs.  Understanding the value of hormone balance and the principles that effect weight, inflammation, blood pressure and cholesterol, the ketogenic lifestyle is one in which carbohydrates are restricted in an individually tailored way to obtain the end goal. How does a ketogenic lifestyle balance mind and spirit?

Step One

Put down your force-field.  This takes courage and it takes faith.  Your force-field is any distraction that keeps you from thinking and feeling and identifying truth.  These include excessive alcohol, illicit drugs, binge eating, smoking, gambling, working excessively or getting lost in repetitive dramatic romantic relationships .

Believe me, the force-field gets heavier every day.  After my father passed away at age 58 from the major complications of diabetes and my sister committed suicide a few years later, I threw myself into work and church service.  I worked 16-18 hour days, completed a second board certification in Obesity Management and a fellowship in Health Policy, all while serving as a bishop and counselor in my church.  I found that I could raise my force-field of justification to hide from the pain and emotions of family illness and depression.

But the force-field saps your energy and cheats you out of seeing your full potential.  I found that as long as I held up my force-field (and some of us care more than one), I couldn’t see the experiences that made me who I am and connect me with those I was trying to serve and help.  As long as I was holding up my force-field, I was living in the fear of re-experiencing the pain of loss and the worry of future disease, . . . and people sense that.

You don’t have to drop the force-field all at once. You don’t have to quit work and become a hobbit. You just have to lower the field a little bit, enough to peek over and let the Eternal Truth shine on you. Truth is a funny and powerful thing.  The more we overcome our reluctance, face the pain and the fear, the more we realize just how often things begin to go well for us.  Living in the presence of great truth and eternal law and being guided by permanent values is what keeps a man patient when the world ignores him, and calm and unspoiled when the world praises him.

Step Two

Identify emotional or behavioral patterns that you want to change. If you don’t know, ask a trusted friend, your spouse, or your relatives. As I think back over the years, I had a couple trusted friends pull me aside and identify a few of those patterns face to face.  I appreciate that, and I’ve never forgotten it.

  1. Make a list of the events in your life that you regret and wish you would have made a different decision.
  2. Go over the list as many times as you need to to identify the pattern or theme that seems to tie the regrets together.
  3. Then actually write down the theme or reason that you identified as the cause. This allows you to identify and remove the corrupted soft-ware of your soul.
  4. This process can take time and is often camouflaged by denial.
  5. Major insight often comes as a knock on the door of denial, so listen carefully to what is being said.  Listen to yourself listening. Psychiatrists say that if something said while listening to a patient makes them suddenly feel sad or irritable, then that may be a meaningful theme in the patient’s life.  Listen to your gut feelings as you go through the day.  Don’t ignore a prompting from your soul.

Step Three –

Realize that today’s negative emotional and behavioral patterns are connected with painful memories and unsolved past conflicts.

Do you get a gut feeling that you want to change the subject when someone brings up a financial setback?  Do you want to reply with one liners like, “I’m sure it will all work out?”  Are there other topics that make you uncomfortable?  Ask yourself why that topic makes you uncomfortable . . . seriously, ask yourself, and then answer yourself.  Do you suspect your spouse of cheating when there is no objective evidence to support the suspicions?  Recognize these uncomfortable feelings are our subconscious waving flags to make us each aware of unresolved conflicts within our mind and spirit.

Remember, we attract the type of energy we give off.

Step Four

Pray to whatever higher power you believe in.  Meditation, prayer and “ponderizing” brings a reservoir of faith and courage to find and to face the truth.  If you have the faith, get on your knees and sincerely ask God for help facing your truth and the challenges, fears and sadness that reflecting upon it may initially bring. I promise you that you will gain the strength to accomplish the task. It will bring the strength to overcome the hidden trauma in your earlier life and will give you the strength to resist the call of ice cream at 3 am.

d_day_courageFollowing these four simple steps, keeps you vigilant to the physical and spiritual warning flags that may arise on your ketogenic journey and will bring great confidence while modifying your diet to balance your body’s hormonal milieu.  Confidence inspires courage.  Those with courage and confidence in themselves, and faith that they are on the right path, are unstoppable. Good luck . . . I look forward to seeing you on my journey down the same path.

Nutritional Values of Brisket . . . on the Fly . . .

My family and I enjoyed some “moist brisket” from Rudy’s Country Store and Barbecue this evening.  This is one of my favorite meals.  I ordered up 2 lbs knowing that I’d have some to save for later this week.  How do you calculate up the ketotic nutritional values for this meal?  Easy.

Nutritional values can often be found on the menu or on the web (you might have to ask for it).  Rudy’s Country Store kindly places their nutritional information on the web and you can locate it here.

Rudy's Moist Brisket

Now, the image above is 2 lbs of moist brisket (with extra bark) and nutritional values are calculated per 1/2 lbs. serving size as noted below.  (No, I did not eat this whole thing.)  I saved 3/4’s of it for another meal sometime in the next few days.

Rudys Moist Brisket Nutrintional Values

The Nutritional facts above can be somewhat misleading if you add up the grams of protein, fat and carbohydrate you end up with 93 grams total (the misleading part is that 93 grams does not equal 1/2 lbs.  The assumption is that the values are “pre-cooked”).   But what I am looking for is the ratio of fat per serving.  One serving size has 50 grams of fat and 41 grams of protein.  54% of this brisket is from fat.  If you eat the entire 1/2 lbs you’ll go over you protein needs for that meal (assuming that I need only 30-35 grams of protein per meal – 3 meals a day).  I only at about 1/3rd lbs. (totally stuffed afterwards) and so 54% of my meal was fat (keeps me in ketosis) and 1/3 lb of the brisket has about 27 grams protein.

Did I calculate all this up before I ate.  Absolutely not.  I just ate and amazingly, I got full somewhere between 1/4 lb and 1/3 lbs.  The key is listen to your body.  It will tell you when you are full (unless you are cheating and eating carbs with it, then all bets are off and the satiety signal is delayed).

By the way, it was delicious.

Peri-Chatting with Dr. Nally – Friday Chat Between Charts

Dr. Nally chats via PeriScope with the four corners of the US . . . Did we see you there?

Join me for Q&A about general #low-carb #ketosis and #ketogenic questions (protein amounts, Vitamin D, fatty liver disease, ketosis and sleep, osteoporosis/osteopenia, and much more) on a Friday evening between charts.

Ketogenic Principles . . . Part II

There are three constants in life: change, choice & principles.   Change, ironically acting as a constant, is the variable that we have limited control over.  Accepting that change is going to happen, that change is constant, and making choices to prepare for those changes is the key to success.  My last post introduced the 10 Principles of the Ketogenic Lifestyle.  This post will discuss choice as a foundation for those principles outlined in the ketogenic lifestyle.  Choices are directly influenced by the balance between the mind, the body and the spirit of man.

LIFESTYLE PRINCIPLE 1 – WHEREVER YOU GO, THERE YOU ARE

People seem to get sidetracked off a ketogenic lifestyle for a number of reasons, but the most common I hear is that they were traveling, had company visit or they were on vacation.  Successfully living a lifestyle requires that you first know who you are and where you are before you can consistently make good, solid, principle based choices. So I ask, who are you?  Are you defined by your job, by your finances, by your travels, by your friends or by your vacations?  Each of these experiences is unique.  Our experiences place both good and bad before us.  I have come to learn over time and countless interactions with people that nothing is coincidental.  Everything, good and bad, happen for a reason.

Today’s society teaches the Pleasure Principle.  This is the human instinct to seek pleasure and avoid pain, including avoiding painful recollections.  We often define ourselves by those things that bring us pleasure.  We each go through personal tests, failures and triumphs. Some of us harness all of those experiences for good, others find worsening mental paralysis due to fear of them. We often hide from the painful experiences and attempt to bury or forget them.  Food is often involved with many of the experiences of life, and for a significant number of people, the endorphin release from eating a meal, sometimes just the act of chewing, may be the only pleasure one experience in a day, in a week or a in a year. Many people hide from painful recollections behind the simple pleasure produced by the eating of “comfort foods.”  Food, and our opportunities to experience pleasure from it’s various flavors, textures and physical stimulus, begin to define us.  However, hiding from life’s painful memories with momentary pleasures usually prolongs or makes the problem worse. The ingestion of simple foods containing glucose and fructose, their effect on the liver, and the hedonistic hormonal response is the basis of addiction, and simple carbohydrates provide the perfect fix.

weight watchers diet pillsFascinatingly, when fructose is metabolized in the liver, in the presence of glucose (the basic structure of sugar – one fructose molecule bound to a glucose molecule), the byproduct has a hedonic (pleasure experiencing) effect on the exact same pleasure receptors in the brain that bind to morphine.   Yes, that’s why the M&M’s make you forget your troubles and why the Jolly Rancher is so jolly.  And, its the same reason you crave another do-nut two hours after you ate the entire baker’s dozen.

Although obesity has been recognized as a disease, our use of foods to celebrate with people or events in life is still a form of pleasure seeking. Excuses to deviate from healthy behavior under the guise of family, vacation, or social requirements, acknowledges our willingness to hide from pain with hedonic drugs like chocolate chip cookies and cotton candy.  In fact, it’s usually a welcomed and and expected acceptable excuse.

“Dr. Nally, I can cheat eat and bad, (meals loaded with starch) because I’m on vacation” . . . from my problems.  It’s so acceptable, we’ve based movie themes around it. Vacation from your problems

Healing can only occur when one is willing to confront and talk about the reasons, the real reasons you’d rather experience the endorphins from the do-nuts with your family instead of acknowledge your weakness, stresses, and fears.  Many of us are so afraid of where we might be, we avoid acknowledging where and who we are.  It takes courage not to take the easy path.  And I will be the first to admit, pizza is the easy path and it’s scenic views are decorated with french fry palms and sunset clouds of apple fritters.

“There appears to be a conscience in mankind which severely punishes the man who does not somehow and at some time, at whatever cost to his pride, cease to defend and assert himself, and instead confess himself fallible and human. Until he can do this, an impenetrable wall shuts him out from the living experience of feeling himself a man among men.  Here we find a key to the great significance of true, un-stereotyped confession – a significance known in all the initiation and mystery cults of the ancient world, as is shown by a saying from the Greek mysteries: “Give up what thou hast, and thou will receive.” (Carl Jung)

We have a choice about what to eat and when to eat, however, each choice has a reward and/or a consequence.

Points of Focus: Where are you and what are you hiding from?  Sharing your weaknesses actually empowers you you overcome them. This can often be accomplished through the simple act of journaling, planing your meals the day before and journaling your successes and failures in that plan the following day.  Allowing yourself and others insight into your times of weakness actually brings strength.  It allows one to look at the reasons for food choices base on how you feel, and how you felt after the choice.  If forces one to think about a choice before it ever has to be made.  In my 15 years of medical practice, I have yet to hear a child find fault with a parent who worked tirelessly to make ends meet, admittedly struggled with alcoholism, battled against disease or fought against belittling for a belief. The child has always expressed their admiration of their parent’s courage and understanding of why decisions were made, even when erroneous. It takes courage to admit that wherever you go – there you are.

LIFESTYLE PRINCIPLE 2 – KEEP IT REAL

Keep it realI no longer believe in coincidence.  Whether you have thought about it or not, every interaction you have with others (even our interaction . . . your reading this blog), are not by coincidence. There is a reason.  Whether you believe it or not, everything around us testifies that God exists; the Hand of Providence can be seen from the rotation of the earth, planets and stars, the precision of the seasons, the balance of the atmosphere allowing for the perfect pressures and concentration of elements to sustain a life giving breath, to the perfect replication of DNA within billions of cells throughout the body.  I’m not trying to get religious, and, no, I can’t prove this through the scientific method . . . But, if the Big Bang started the universe, what started the Big Bang?  Where did the first atom or molecule or particle of dust come from?  I have a very difficult time accepting that you and I are here by accident, by a chaotic explosion that created order.  That implies that there must be a plan, and that plan had to have been set in motion by a Creator.  That also implies that that Creator placed solutions to our challenges, including the diseases of civilization, within our grasp and available to those seeking the solutions upon the earth today.

I have seen enough in my medical career to know that simple coincidence has frequently become significantly important, life changing and often life saving. This does not happen by accident and screams loud and clear that there is a plan for you and me.  No good father would lock his child in a room without doors or windows or any escape without everything in the room, both good and bad, pointing to the reason the child was in the room, and pointing the way for the child to become his or her best self, physically and emotionally.  Life has meaning. It is supposed to. If we get off track, coincidence and interactions lead us back.

“Behold, the hour cometh, yea, is now come, that ye shall be scattered, every man to his own, and shall leave me alone: and yet I am not alone because the Father is with me.” (John 16:32)

The Bible, among other records, records the voices of men and women from years past transcribing their experiences with the Hand of Providence, how that spiritual void was filled, how it helped the with choice and how our lives have deeper meaning and consequence, even amidst significant adversity.

Take a week and look at the synchronicity of your life.  Journal about it.  Don’t dismiss a second invitation from someone to discuss an opportunity or meet someone your friend thinks could be important to you, open that book that someone left behind on the subway seat beside you. Don’t assume it is meaningless, that some kind person returned your sunglasses or your wallet.   Look at the simple interactions and recent relationships.  These are the breadcrumbs and the street signs from a loving Creator, a loving Father.

Keeping it real means nothing less than complete authenticity.  The last place you want to be is in the first-class seat on the plane to no-where.  Have the faith to get off the plane and take the bus, ride your bike, or even swim upstream in the direction you’re supposed to be going. Look for the coincidences, bread crumbs and spiritual street signs in your life.

How does this relate to a ketogenic lifestyle?  Every religion or spiritual tradition speaks of a polestar.  The polestar is that anchor to which the entire solar system is tied by invisible aerial chords and the engine that powers the universe.  Those cords are connected with our own individual polestars.  A ketogenic lifestyle is one that encompasses mind, body and spirit.  It is a lifestyle that demands that you link and align your personal polestar with the truth inside and around you.  It takes both courage and faith, but it brings immeasurable strength and help in achieving your goals.  A person out of balance with life is under stress.  Chronic stress produces excessive cortisol and other powerful adrenal hormones that displace the body’s and the mind’s endocrinologic balance, leading to weight gain, weight retention, and chronic disease.  This often has significant effect externally on the body in processes seen like depression, anxiety, fibromyalgia, and allowing for amplification of inflammation and auto-immune dysfunction.  We refer to this inter-relationship in the medical community as psychosomatic and/or viscerosomatic dysfunction, the psyche (the mind) and/or the viscera (internal endocrine organs) directly and adversely influence the function of the soma (the structural body separate from the mind).

“He who does not know himself, does not know anything, but he who knows himself, knows the depth of all things. 

” . . . If you bring forth what is within you, what you bring forth will save you. If you do not bring forth what is within you, what you do not bring forth will destroy you.”  (Book of Thomas the Contender)

Point of Focus: Your life is never without meaning. Keep it real by recognizing that diet alone may not compete your answer for physical health.  Having courage and faith allow you to see and embrace the truth that is right in front of you. The  Alcoholics Anonymous’ 12 step program only becomes successful when one realistically and courageously applies their faith to align with the truth they have felt all along.  For any long-term lifestyle change to take place, one must connect and live the principles before one truly knows they are true.  In this way the Ketogenic Lifestyle becomes real.

KetoOS
KetoOS – Drinkable Exogenous Ketones

LIFESTYLE PRINCIPLE 3 – TO cheat, or NOT to cheat, that is the question

cheat mealI have been asked this question by every patient I have placed on a ketogenic diet at least once and often three or four times throughout the course of our treatment plan. I usually answer this question with a question. “Why do you want to cheat?”

The desire to cheat usually arises form one of three reasons:

  1. You’re not eating enough fat to satiate your appetite and you are truly hungry.  The body recognizes that it can use and absorb glucose much faster than fat, as fuel, so it naturally will crave “sweets.”  In this case, the case of true hunger, solution is to increase your fat intake.  You should be eating at least 50% of your total calories in the form of fat.
  2. Insulin loads are still high, stimulating rebound hunger and hedonistic cravings. You’re either eating too many carbohydrates with your diet or you’re using a sweetener that stimulates insulin without raising blood sugar  (See my article The Skinny about Sweeteners).
  3. Cheating with a specific food fulfills a psychological need, feeds an addiction or represents an obligation to fulfill a societal ritual. Journaling helps to identify and break this cycle.

If you are truly in ketosis the cravings to cheat don’t exist, they actually disappear.  Other societal rituals, like birthdays, anniversaries, weddings, spiritual ceremonies or rites of passage are often tied to or use food as symbolism.  In these cases, the decision to cheat is really yours.

When a person cheats, it can take as many as 3-5 days to get back into ketosis, and for some 2-3 weeks.  Carbohydrate cravings will rebound and often be present for up to 72 hours after cheating. You have to decide if cheating is worth 3 days of carbohydrate cravings and 3-7 days of stifled weight loss.

Point of Focus: There are no Ketosis Police! Really. They don’t exist!  Dr. Nally will not show up in uniform on your doorstep with a set of handcuffs and a bag of pork rinds. You won’t be arrested for eating bread and those of us who have been following a strict ketogenic lifestyle for years really don don’t mind at all if you decide to cheat.  We will smile and we may even ask you how it tastes or if you liked the flavor, but don’t be self-conscious, because when one is in ketosis for a few months, we really don’t crave cheating any longer, and we won’t judge you. And, don’t feel obligated to justify why your cheating, this is a lifestyle.  You probably won’t ask me why I chose to wear long sleeves on a hot day in Arizona, for the same reason I won’t ask you why you decided to wear a Speedo.

LIFESTYLE PRINCIPLE 4 – Hunger Management

Man-vs-Shark_11Life comes at you pretty fast and if you’re not prepared, hunger can bite you.  Most people fall off the wagon when they are unprepared for missing a meal on a stressful day. I’ve recently heard the argument that “there is no wagon, so don’t worry about falling off.”  This is false security that leaves one unprepared for life events.  Pioneers traveled in wagons for two reasons.   First, the wagon held supplies essential for survival.  Second, wagons usually traveled in wagon trains.  This means that there was more than one person on the wagon and there was more than one wagon on the trail with you. Traveling with a wagon train meant you had others on the same trail with the same tools for safety and support.

In the world of fast foot, fast photos and speedy delivery, we often don’t adequately prepare for hunger or cravings.  There are some essential hunger management tools for the Ketogenic Lifestyle:

  1. Eat meals containing >50% fat.  This, in and of itself, delays hunger and ensures the satiety center of the brain is happy for longer periods of time.
  2. Carry rescue foods with you or keep them at your office or in your fridge at home. These include low-carb nuts like almonds, walnuts, macadamia nuts; Keep hard and string cheese handy for a snack.  Use sliced deli-meats with the cheese as a snack when the cravings kick in.  Pork Rinds, beef jerky, olives, are great natural food options.
  3. If you have time and can cook, develop your favorite “Fat Bombs and have a bag full in the fridge for those cravings.
  4. Having the moral support of a buddy, spouse, friend or work companion who checks on your progress daily, assists with meals and meal choices is priceless. Periscope, a free Twitter based App, has become a means of checking in with your Ketogenic Support group around the world that connects to those you follow on Twitter.  You can follow me, @docmuscles, and a number of fascinating health Periscopes that focus on ketogenic, low-carb, whole food paleo approaches:  @livinlowcarbman, @_danielleeaton, @kasandrinos, @fatissmartfuel, @domskitchen, @mikemutzel, @keribrewster, @tombilyeu, @glutenfreenj, @paleocomfort.
  5. Being accountable to yourself in a diet journal daily and to your doctor regularly every 1-2 months also helps keep motivation going forward. Jimmy Moore, author and podcaster at the Livin’ La Vida Low-Carb Show has also posted one of the most extensive lists of physicians specializing in ketogenic diets from around the world.  You can find that list here.

LIFESTYLE PRINCIPLE 5 – Stress Reduction

Pages and pages can be written about stress reduction.  In fact, I’ve written about the chemical responses that stress has on weight gain in my post, Stress. . . The Weight Loss Killer.  But there are a few daily essentials that should be added into the Ketogenic Lifestyle to manage stress.

First, are you getting adequate sleep? Remove the television, computer, cell phone, iPad or other electronic distraction from the bedroom.  Go to bed at the same time and get up at the same time each day. Give yourself time each day away from being plugged in, logged in or on-line.

Second, over exercising or being malnourished can cause chronic stress. I have a number of patient that have been convinced that they have to work out 60 minutes a day 6-7 days per week.  It is essential that you realize muscles need a minimum of 48-72 hours to recover from specific types of exercise.  If you run for 60 minutes.  It will take your muscles 48 hours to recover from the running. If you do upper body weight lifting, it will take 48-72 hours for those muscles to recover from that weight lifting.  Exercising the same muscle group with the same exercise over stresses the muscles and leads to significant chronic stress, spiking the cortisol levels and halting weight loss and raising cholesterol & triglycerides.  Under eating or fasting to starvation has the same effect.

Third,  mild intensity (40% of your maximal exertion level) exercise 2-3 days a week was found in a recent study to lower cortisol and decrease over-all stress, raising serotonin and dopamine in the brain; however, moderate intensity (60% of your maximal exertion level) to high intensity (80% of your maximal exertion level) exercise was found to raise it.  A simple 20 minute walk, 2-3 times per week is very effective at stress reduction, reduction in cortisol and improvement in ketosis.

Point of Focus: The goal is cortisol reduction. This can be done through regular and restful sleep and mild exercise. Chronic elevation in cortisol directly stimulates an increase in insulin by increasing the production of glucose in the body, and cortisol blockaids the thyroid axis. Both of these actions halt the ability to loose weight, amplifies the production of inflammatory hormones and drives weight gain. Cortisol also increases appetite.  That’s why many people get significant food cravings when they are under stress (“stress eaters”). Cortisol also indirectly affects the other neuro-hormones of the brain including CRH (corticotrophin releasing hormone), leptin, and neuropeptide Y (NPY). High levels of NPY and CRH and reduced levels of leptin have also been shown to stimulate appetite.

Hopefully, this gives you some starting points and direction to your Ketogenic Lifestyle.  If I’ve missed something that you’ve found to be essential, let me know. Its always great to hear what has helped you in your Ketogenic journey.  Until next time, pass the butter!!!

Nutritional Values of Commonly Used Ketogenic Foods

I’ve had a number of emails and requests from patient’s to locate a source for fat percentages and protein contents of various foods as they prepare and follow a ketogenic lifestyle.  I’ve looked all over, however, nothing easy and concise has made itself readily available, and there hasn’t been a simple one page tool at your fingertips . . .

Hopefully, this list will start to fill that gap.  Use the list to calculate protein and fat levels as needed.  Let me know if I can add to the list or if there are foods you commonly use that I’ve missed.  Keep the ketones up and your waistline down!

Nutritional Values of Common Ketogenic Foods:

Food:                                                                       Protein Contents:                                Fat Contents:

Steak (Ribeye) –                                                      65 grams per 8 oz.                                 49%

Steak (Top or Bottom Round) –                             23 grams per 3 oz.                                  33%

Ground Beef (75% Lean) –                                      22 grams per 3 oz.                                 55%

Pork Chop (boneless) –                                            26 grams per 3 oz.                                15%

Ham –                                                                      17 grams per 3.5 oz.                              12%

Bacon (grilled) –                                                      22 grams per 3.5 oz.                               75%

Sausage (beef) –                                                     14 grams per 3.5 oz.                              79%

Sausage (pork) –                                                     17 grams per 3.5 oz.                              75%

Chicken Breast (boneless, skinless) –                     24 grams per 3 oz.                                  18%

Turkey Breast –                                                       24 grams per 3 oz.                                  15%

Yellowfin Tuna –                                                     25 grams per 3 oz.                                  10%

Light Tuna –                                                             22 grams per 3 oz.                                 8%

Halibut –                                                                  23 grams per 3 oz.                                  19%

Sockeye Salmon –                                                   23 grams per 3 oz.                                  22%

Tilapia –                                                                   21 grams per 3 oz.                                  13%

Deli Meats:

Roast Beef –                                                            18 grams per 3 oz.                                  16%

Canadian bacon –                                                    15 grams per 3 oz.                                  33%

Pepperoni –                                                             18 grams per 3 oz.                                  83%

Roast Turkey Breast –                                             18 grams per 3 oz.                                  15%

Snacks:

Beef Jerky (Jack Links) –                                          13 grams per 1 oz.                                9%

Peanut Butter (Peter Pan Crunchy) –                      8 grams per 2 tbsp.                                76%

Mixed Nuts –                                                           6 grams per 2 oz.                                    79%

Almonds, raw –                                                       6 grams per 1 oz.                                    66%

Walnuts, raw –                                                        4 grams per 1 oz.                                    85%

Sunflower seeds, raw –                                          6 grams per 1 oz.                                    76%

Tofu –                                                                      12 grams per 3 oz.                                  30%

Greek Yogurt –                                                        23 grams per 8 oz.                                  0%

Cheeses:

Swiss Cheese –                                                        24 grams per 3 oz.                                  66%

Cream Cheese –                                                      11 grams per 3.5 oz.                               79%

Ricotta cheese –                                                      10 grams per 3.5 oz.                               63%

Cheddar cheese –                                                    24.6 grams per 3.5 oz.                            74%

Eggs –                                                                      6 grams per 1 large egg                         60%

(Adapted from http://www.caloriecount.com)

A printable PDF copy of this information is available here:

Nutritional Value of Common Foods.

To live in the presence of great truths and eternal laws, to be led by permanent ideals –  that is what keeps a man patient when the world ignores him, and calm and unspoiled when the world praises him.  Hopefully, these posts are adding to your stable ideals.

How Much #Protein is Too Much on a #Ketogenic Low-Carb Diet? #DocMusclesScopes

How much protein should you be using?  Watch the periscope below . . . and good morning from Surprise, Arizona!!

I’ve included the calculations you will need to get a ballpark estimate on your protein intake from your ideal body weight

Ideal Body Weight (IBW):
These calculations are estimated ideal body weight in kilograms (kg).  You can convert your weight in pounds (lbs) to kilograms (kg) with the following formula:

The average male needs 1.2 mg/kg protein per day.  The average female needs 1.0 mg/kg protein per day.

Males:

IBW = 50 kg + 2.3 kg for each inch over 5 feet.

Females:

IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.

Examples:  If I am 6 feet tall, as a male, then I add 50 kg to 27.6 kg ( 6′ tall is 12 inches over 5′ x 2.3 kg) = 77.6 mg of protein requirement per day.  That means that if I (a 6′ tall male) ate three times a day, then my protein requirements are 25.9 mg per meal.

Ordering the Low-Carb Ketogenic Burger

Running some errands this morning and the tummy became a little rumbly.  That’s my sign that it’s time to fuel the Doc’s Muscles.  My son and I love Five Guys.  They make a mean burger and cater to my every Ketogenic whim.

Here was today’s burger:

The lettuce wrapped bacon burger with mustard (and a pickle just for some flair).  Pure saturated fat awaiting ketosis wrapped in foil. (Kind of makes your mouth water, doesn’t it?)

Five Guys Bacon Burger with Mustard

Add the bacon for a little more fat and the mustard for flavor and to prevent leg cramps (yellow mustard contains just enough quinine that it stops leg cramps) that can occur with dehydration in the Arizona heat (it was 93 degrees F today) and I’m a happy man.

Hope your lunch was just as good.

Low-Carb Maple Pecan Granola . . . (No More Frowney Faces) a DocMuscle’s Favorite

Frowney Face Child

The most exaggerated “frowney” face I get in the office seems to occur when patient’s find out that they cannot eat oatmeal or cereal any longer when following a low-carbohydrate dietary lifestyle.  No, oatmeal is NOT good for you . . . I don’t care what WebMD recently said.  No, steel-cut oats are even worse (1/4th cup of steel-cut oats is 27 grams of carbohydrate – Who only eats 1/4th cup of oatmeal? Most people eat at least 1/2 -1 cup at a sitting.  You do the math . . .)

When I mentioned this to a disabled patient, even her service dog frowned.

Frowny Face Dog

Now, before you go running to Larry, the Quaker Oats Mascot (he’s been around for over 140 years), and ask his weight loss advise, I have the solution.

Larry, the Quaker Oats mascot loses 10 lbs for new 2012 cover (He finally figures it out after 137 years)
Larry, the Quaker Oats mascot loses 10 lbs for new 2012 cover (He finally figures it out after 137 years)

My angelic wife, Tiffini, the amazing homestead chef and animal husbandry specialist on our little farm, started making low-carb granola for our horseback trail rides.  Prior to our discovery of a ketogenic lifestyle, granola was a staple in our pantry, on road trips and in the saddle bags on the trail.  This has now replaced any craving either of us had for granola.  It carries nicely all day in a Ziplock bag on horseback.  It even tastes fantastic in a bowl with unsweetened almond milk as a breakfast alternative if you’re tired of eggs and bacon (but, who ever tires of eggs and bacon? I know . . . Right?!!)

Low Carb Granola

I’ve been nibbling from this actual cookie-sheet of low-carb granola while writing this post. . . I wish you were here to share it with.  Soooooo very good, and good for your ketogenic lifestyle.  I think I’m going to eat another handful while I finish up Part II of the Principle Based Ketogenic Lifestyle post.  Enjoy . . .

—————————————————————————

Tiffini’s Maple Pecan Granola (Low-Carb)

1/4 cup butter
1 1/2 cup almonds
1 1/4 cups pecans, divided
1 cup flax seed meal
1/2 cup sunflower seeds – salted
1 cup coconut flakes, unsweetened finely chopped
1/2 cup vanilla whey protein powder – we like ISO-100
1/2 cup pepitas (pumpkin seeds), salted
1/8th tsp stevia extract
1 pinch of salt
2 egg whites
1 tsp EZ Sweetz (or 1/2 cup of Sweet Perfection)
In a food processor, process the almonds and 1 cup of the pecans until it resembles coarse crumbs.   Using a knife (preferably a sharp one – remember all bleeding stops eventually), chop the remaining 1/4 pecans coarsely.
Melt the butter and place it in mixing bowel or mixer (We use a Kitchen Aid Mixer).    Pour the coarsely chopped nuts into the mixing bowl.  Stir in flax seed meal, sunflower seeds, coconut flakes, pepitas and vanilla whey protein powder.  Blend in the remaining wet mixture, egg whites and add a pinch of salt.  Mix until it forms “clumps.”
Spread the mixture evenly on a large wax paper covered baking or cookie sheet and bake at 350 degrees F for 20-25 minutes or until golden brown.  Let it cool on the baking sheet to crisp up for a few hours.
It can be stored in a Ziplock bag in the refrigerator.
Yields 10 servings
1/3rd cup per serving
~ 4 g net carbs
14 g protein
30 g fat
Recipe was modified from Carolyn Ketchum’s Maple Pecan Flax Granola in Low-Carbing Among Friends, Volume – 1, pg. 169, Eureka Publishing, 2011.

The Principle Based Ketogenic Lifestyle . . . Part I

BalanceIt has been resoundingly clear to me over the last couple of weeks that there is a tremendous need for a principle based approach to a ketogenic diet.  This approach, however, must be simple.  So many of the approaches to weight loss I read about are complex and the questions that arise from these approaches are innumerable.  Losing weight should not be as difficult as putting a man on the moon.  To quote a patient recently, “If it ain’t simple, Doc, I ain’t doing it. . .”

I agree.

Any approach that requires the conversion of food to numbers or calories or exchanges becomes cumbersome, and I personally won’t follow it for more than a week.   The principle based approach should be simple and is really based upon the mantra:

Give a man a fish and he will eat today. Teach a man to fish and he will eat for the rest of his life. 

Ketogenic diets are wrongly referred to as diets.  What I’m talking about is a ketogenic lifestyle.  Simple lifestyle design should not be hard. So, what do you say? Shall we learn to fish?!

I assume that if you’re reading this article, you already understand that weight gain is not due to an over intake of calories.   Weight gain is due to hormone signals throughout the body leading to the storage of fat . . . specifically, triglycerides being taken up into the fat cells.  The hormone that independently controls uptake of fat into each fat cell is insulin.  Insulin is an essential hormone, but too much of it stimulates the adipose (fat cells) to over-stock triglycerides or essentially “get fat.”  It, actually, is that simple.  There’s really only one rule to this lifestyle: If it raises your insulin it will halt or stall your weight loss.  Write that on your hand or your forehead or in your planner, the lifestyle revolves around that one rule.

Most people start a ketogenic diet because they want to lose weight and have failed at multiple other dietary approaches. Reasons for weight control failure are often multi-faceted, but they all start with from a position of flawed understanding. The majority of approaches to weight management come from  the false assumption that weight is gained because of an over-consumption of calories or a lack of physical activity to burn excess calories.   People have faithfully been restricting calories and exercising to exhaustion since the early 1980’s to no avail. (Well, 1% of people succeed, but the rest of us failed this approach). The definition of insanity is repetitive completion of an ineffective action and expecting a different outcome each subsequent time around. If you still think that caloric restriction and exercise is successful, I’ll be shipping your drawstring white vest and your invitation to a padded cell shortly.

Let me put it clearly.  We’ve been exercising and cutting our calories since 1975 and look at what it’s gotten us . . .

Obesity Trends 2015

. . . . a country that is now recognized as the “United States of Corpulence.”  Super-Size me has become literal. “Houston . . . we have a problem . . . !”

houston-we-have-a-problem

The rule above is based on foundational principles.  Understanding of the principles allows one to successfully apply the rule above.

PRINCIPLE 1

The first principle in a ketogenic lifestyle is understanding that the problem is not caloric, but hormonal.  Choices and actions from here on out must be based on this understanding.  Anything that will raise insulin will thwart ketosis. Insulin stimulates lipoprotein lipase, the enzyme that pulls the triglycerides into the fat cells. Without insulin, we don’t gain weight. (That’s why type I diabetes are usually very slender and skinny).

The standard lab value for normal fasting insulin levels reflect 10-22 uIU/L as the normal.  However, in my office, glucose tolerance tests and postprandial glucose tests consistent with impaired fasting glucose are routinely positive when the fasting insulin level is >5 uIU/L.

Point of Focus: If your having trouble, look at the hormones.  Food stimulates hormone responses. Focus on the hormone response to your diet.

PRINCIPLE 2

A ketogenic diet is one where the body uses fatty acids as the primary fuel. Those triglycerides mentioned above are made up of three fatty acids linked to a glycerol molecule.  To use the triglycerides, the three fatty acids must be broken away from the glycerol by hormone sensitive lipase (HSL).  Insulin directly inhibits HSL. Keeping insulin levels low is the first step in shifting to a ketogenic metabolism. Lowering insulin allows access to the fatty acids in your fat cells.  Triglycerides are not water soluble and the rate by which they can be taken up and burned in the mitochondria limits the speed by which triglycerides can be used as fuel. The by product of triglyceride burning is ketones.  Ketones themselves can be used as fuel and over 4-6 weeks, the body can enhance its ability to use ketones when fat is the primary fuel. This is called “Keto-Adaptation.”

Point of Focus: Too much carbohydrate in the diet shifts the body from it’s use of fat and triglycerides back to glucose.  In general, to become “keto-adapted,” limit carbohydrate to < 20 grams per day.  Keep protein at around 0.8 to 1 gram of protein per pound of body weight.

KetoOS
KetoOS – Drinkable Exogenous Ketones

PRINCIPLE 3

Wait a minute!? Where do the ketones come in? When fatty acids are burned or oxidized in the mitochondria of cells within the liver, they are converted into Acetyl-CoA.  The Acetyl-CoA is used to form ATP for energy in the Citric Acid Cycle.

Metabolism macronutrients

IF excess Acetyl-CoA production occurs or if inadequate oxaloacetate is present, the extra Acetyl-CoA is transformed into ketone bodies – specifically beta-hydroxybutyric acid and acetoacetic acid.  Fat can be oxidized or burned for fuel while ketones are being produced.  Ketones are much smaller molecules and can more easily be transported in the blood than triglycerides, as they are water soluble. The ketones themselves can also be used or burned as fuel as the body upregulates the mitochondria’s ability to use the ketones as fuel as well.  As I mentioned above, this process of “keto-adaptation” can take 4-6 weeks. Keto-adaptation results in humans having a greater desire to be physically active – the miraculous conversion of the couch-potato into the bacon-burning triathlete.

Point of Focus: Sugar is a drug.  Its byproduct has the same hedonic effect on the brain as morphine.  Sugar withdrawal can commonly cause headache, anxiousness, insomnia, dizziness, fatigue and moodiness within the first week of carbohydrate restriction on the road to keto-adaptation.

Ketone_bodies

PRINCIPILE 4

For the average person to become “ketotic” or reach a state of ketosis, it takes lowering the carbohydrates to less than 20 grams per day (and sometimes less than 10 grams per day) for at least 3-7 days.  Yes, it can actually take a week to reach ketosis.  I have a few patient’s that are so insulin resistant that it takes longer.  This means that to reach that fat burning state, one must maintain a low insulin response by restricting starch or carbohydrate intake to less than 20 grams per day for a minimum of a week.  For your body to efficiently use the fuel it can take up to 6 weeks.  This is why many people state that they “don’t feel good” or “can’t maintain their exercise levels” when starting a ketogenic diet. For most people, once they reach the 6 week mark, mitochondria have been unregulated and “fine tuned” to burn ketones, fat burning becomes efficient and energy levels begin to increase. In fact, for many like myself, you’ll finally feel like exercising for the first time in you life.

Point of Focus: If you’re already exercising, don’t be surprised if you feel more sluggish for the first four weeks.  If you’re not exercising, I don’t recommend starting until after you pass through the Keto-Adaptive phase.

MIchelin Tire Man Pondering

PRINCIPLE 5

Clinically, the average patient in my office will lose 5-15 lbs each month for the first three months. Then the weight loss will slow to 2-5 lbs per month. However, 1/2-1 inch continues to disappear off the waist circumference measurement every month.  THIS IS NORMAL. Continued weight loss of 15 lbs a month will leave you looking like the Michelin Tire Man – rolls of skin without fat. The body slows the weight loss to keep up with skin and connective tissue remodeling.  As long as ketosis is maintained, the fat will continue to melt away.  At this point, I’m not so worried about scale weight as I am your waist circumference.

Point of Focus: Successful ketosis does not always affect the scale, but usually causes your pants to fall down.

PRINCIPLE 6

It has been my experience that it takes about 18 months for the average patient to reverse the insulin resistance while following a carbohydrate-restricted, high-fat ketogenic lifestyle.  There is no quick fix for this. If there was, I’d be sitting on a beautiful beach in the Caribbean.

Point of Focus: The Ketogenic dietary lifestyle is actually the antidote to insulin resistance, diabetes and the diseases of civilization.

PRINCIPLE 7

Improvement in insulin resistance has also been demonstrated with mild to moderate intensity resistance exercise.  Moderate intensity resistance exercise is 20-30 minutes of exercise like walking, easy jogging, cycling, lifting weights, yoga or Pilates with speeds or weight heavy enough to break a sweat, but not so fast or heavy that you cannot carry on a conversation with your exercise partner.  Exercise improves insulin resistance – BUT IT DOESN’T CAUSE WEIGHT LOSS!  Yes, I know, Jack LaLanne just rolled over in his grave.  But, let me say that again.  Exercise improves insulin resistance, but it does not improve weight loss!! The three largest and most intensive studies of exercise involving over 67,000 people demonstrate that you can exercise till the cows come home and you’ll average about 1% weight loss.  If you exercise, realize it WILL make you hungry.  Eating the wrong food (carbohydrate containing foods) will stimulate insulin release causing your exercise to be fruitless (Actually, your diet should be “fruit-less” anyway)

Point of Focus: Exercise because you feel like it, it improves insulin sensitivity and it decreases stress, not for weight loss.

HungryPRINCIPLE 8

If you are eating enough fat, you won’t be hungry. Although this doesn’t always hold true in the case of patient’s with lepin resistance.  40-60% of patients with insulin resistance have a concomitant leptin resistance (see the article on lepin resistance here).  A ketogenic diet is one in which 50% or more of total calories come from fat.  No, you don’t have to count calories, just pick foods that contain 45% fat or more.  Look for grass fed products as they will be higher in Omega 3 fatty acids.  Red meat is 55% fat. Pork is 45% fat. This is where the chicken salad or turkey wrap fails (see Why Does Your Chicken Salad Stop Weight Loss).  Look for alternatives to replace your basic meals and snacks.  If you love chips, try pork rinds or make chips from fried cheese or pepperoni.  Guacamole is a great replacement for bean dip.

Point of Focus: There is no need to eat 3-6 times per day.  As you increase the fat in your diet you will feel more full.  Eat when you are hungry, whether that is 3 times a day or once day, listen to your body.

Adapt Your Life

PRINCIPLE 9

I’ve been following a ketogenic diet for over 10 years.  The most common complaint I hear is,  “Dr. Nally, I’m tired of eating eggs.”  Ketogenic diets don’t have to be boring. There are hundreds of resources on the web for spicing up your ketogenic diet. See the Recommended Sites page above for some ideas to start. The Ketogenic Cookbook by Jimmy Moore and Maria Emmerich is a recent edition to the literature and a fantastic resource. Check out Franziska Spritzler’s Low Carb Dietitian website and new book as well. If you live in the UK, you should see Emily Maguire’s website and blog.  She just completed a world tour, sampling all the low carbohydrate foods and restaurants around the world.  If you are a picture person, check out the Best Keto Meals of 2015 Pinterest page followed by almost 16,000 people.  If you haven’t takent the time, you should visit Dr. Andreas Eenfeldt’s website.  He is one of Sweden’s premier ketogenic doctors has an immense number of resources at his website, Diet Doctor.  Finding someone that can help you fine tune your diet is also essential.  You can find a list of doctors that use ketogenic diets here.

Point of Focus: This lifestyle will require you to use real, whole food and cook like your grandmother or great grandmother did in the past.  Unfortunately, we’ve lost a great deal of the art of cooking that needs to be re-discovered. If your lifestyle is too busy to cook and prepare real food, that busyness is probably causing you stress, another culprit in the weight gain cycle.  The truth will set you free, but it will probably make you miserable first.

PRINCIPLE 10

WARNING!  A very sweet patient of mine was given these instructions to treat her weight and blood sugar abnormalities.  She applied these principles and they worked marvelously.  She called me a few weeks later, however, mad as a wet hen.  She placed her husband (not my patient at the time) on the same dietary changes.  Her husband, who had significant blood pressure problems and was on four different blood pressure medications I later found out, had a sudden drop in his blood pressure and passed out.  As happens to many of my patients, blood pressure, ejection fraction of the heart and blood sugars quickly begin to normalize.  However, he never saw his doctor and never had is blood pressure medications adjusted.  Because of the normalization that can occur in as rapidly as 1-2 weeks, the medications became much too strong, he passed out and ended up in the emergency room. These dietary principles are effective. They are often just as powerful as a number of the medications that we routinely prescribe.

Point of Focus: Please see your doctor before beginning any of these dietary recommendations, especially if you have any underlying medical conditions including Hypertension, Diabetes, Congestive Heart Failure, Coronary Artery Disease, Gout, Kidney Stones, etc., please do not try the dietary changes alone.  Find a physician trained in the use of this type of dietary lifestyle in combination with close monitoring of your blood pressure, blood sugar and other key vital signs.

Stay tuned for Ketogenic Principles . . . Part II in the series where we’ll address Food Psychology, To Cheat or Not to Cheat, and Keeping it Real . . .

The Simple Effects of Ponderizing . . . The First Step in a Principle Based Ketogenic Lifestyle

I have found, over time, that happiness in life seems to be the greatest when I strive for balance in the three basic aspects of life: Mind, Body & Spirit.  Yes, I am a physician, and I spend the majority of my day applying advise and treatment plans that have been demonstrated to be effective through the tried and true scientific method.  However, I know from personal experience, and from working closely with patients for over 15 years, that science alone, does not bring fullness and happiness to life.  Truth and learning can be found through study and also by faith. Finding balance and peace physically is important, but finding that balance emotionally and spiritually are often essential.  Being able to follow a Ketogenic Lifestyle effectively over the long term (longer than 6 months) actually requires understanding of some basic principles.  This is the first in a series of articles regarding The Principle Based Ketogenic Lifestyle.

Ponder LifeI treat patients with obesity, one of the most difficult diseases to address in the medical office.  I find that just applying diet alone doesn’t always solve the problem.  If the patient’s life is out of balance emotionally or spiritually, the stress this causes often halts effective weight loss and metabolic healing.  You may disagree with me on political or religious issues, but healing is not about politics nor is it about religious doctrine – it is about understanding where we are, the path forward, and our potential to get there.  The mind, body and spirit are deeply interconnected.  Often, until we recognize and treat those connections, true healing cannot occur.

The first step in treating any illness, including weight, is recognition of the problem. The Medical Community has recognized Obesity as a disease, but obesity is also a symptom of underlying physical metabolic dysfunction that may be tied to the mind and spirit.  Daily journaling is the tool that lets one see if the dysfunction is tied to mind or spirit.  I ask my patients to keep a daily food journal.  This is very important in looking at the patterns of macro-nutrient intake.   But the more powerful effect of journaling allows one to see how food is tied to emotion – mentally and spiritually.

Simply writing down what you eat each day, when you eat it, and how you felt after you at it is actually quite profound.  The patterns that emerge are usually seen and identified by the patient long before I ever see them.  In fact, patient’s often bring those patterns up before ever showing me their food journals.

I’ve found, in keeping a food journal myself, that combining my journaling with other other daily goals, uplifting thoughts and reminders was even more helpful and powerful.  This can be done on paper, a notebook, a planner or even on the computer.  (I have a few patients who are accountants or engineers – they bring in complex spread sheets).  What is important is daily consistency.  It takes about 3-4 weeks of journaling to begin to see patterns.

I have taken the advise of one of the leaders of my church to “ponderize” a scripture, meaningful poetic verse or truth filled quote each week as part of the journaling process.  He defined “ponderizing” as the act of pondering and memorizing a scripture or a favorite uplifting poem or verse each week.  This is done by writing the verse on a written card or note in a place that you will see it frequently each day during the week.  When you see it, read it and ponder it.  Just the process of frequently reading it will lead to memorization each week.  I have found that reading and pondering a verse 3-4 times a day for a week, lends itself to easy memorization.  Each time you read the verse, think about it and ponder it for a moment, then go on with your day.  This will give you a brief opportunity to elevate your thoughts each day, and will give you a place your mind can go and think when you don’t have to think. It gives your subconscious mind the ability to solve complex patterns at a higher level.

Said David O. McKay, “Tell me what you think about when you don’t have to think, and I’ll tell you what you are.”  “As a man thinketh in his heart, so is he . . . ” (Proverbs 23:7).

PonderingFor some reason, with all the cares of the day, work, family and the challenges of life, I have fallen out of this habit for some time.  When this leader mentioned this process in his comments, I was reminded of the peace and balance I used to feel each week when doing this simple activity.  I have recommitted myself to restart this activity and I invite you to do the same.  This time to ponder opens your mind and allows you access the deeper worries and fears holding you from what you what to accomplish.  It takes great courage to make permanent lifestyle and dietary changes.  When someone can’t clearly see what lies ahead, it fills them with fear, doubt or both.  But journaling, even in its simplest form, gives a person the ability to resist and then master the patterns that have kept them from change.  As Mark Twain said, “Courage is resistance to fear, mastery of fear – not absence of fear.”

Courage is tested when we purse difficult goals, fight against disease with unknown outcomes, or work to regain health.  The testing can be painful.  Journaling, and ponderizing in the process, gives courage to take small steps, one day at a time.   Admitting to, journaling when we fail or make mistakes, fear of failure or feeling unsure actually increases our courage.  Being given a week to ponderize an uplifting scripture or verse enhances that courage .  Journaling successes and failures empowers us individually.  The psychiatrist Carl Jung wrote:

“There appears to be a conscience in mankind which severely punishes the man who does not somehow and at some time, at whatever cost to his pride, cease to defend and assert himself, and instead confess himself fallible and human.  Until he can do this, an impenetrable wall shuts him out from the living experience of felling himself a man among men.  Here we find a key to the great significance of true unstereotyped confession – a significance known in all the initiation and mystery cults of the ancient world, as is shown by a saying from the Greek mysteries: ‘Give up what thou hast, and thou will receive.'”

Journaling and ponderizing allows one a form of confession and renewal. It gives one courage that you have survived today’s challenges and seen the pattern of fallibility in them.  It is actually energizing.  And, the path to healing begins to become clear.

Journaling also is a great way to outline side effects from carbohydrate withdrawl that will last for 2-4 weeks (That’s for another blog post, however).

Feel free to ask me about the verse that I am ponderizing each week. I will happily tell you which verse I am pondering and memorizing; but, I will in tern, ask you which verse you are ponderizing.

This week, the verse I am ponderizing comes from the Bible – Genesis 35:2-3:

“Then Jacob said unto his household, and to all that were with him, Put away the strange gods that are among you, and be clean, and change your garments: And let us arise, and go up to Beth-el; and I will make there an altar unto God, who answered me in the day of my distress, and was with me in the way which I went.”

Did you begin your food journal?  And, what verse are you going to ponderize this week?

Dr. Nally Featured on Periscope – Jimmy Moore's 100th Broadcast

My Special 100th #Periscope: Announcing A Brand New #Keto Podcast With Me & Dr. Adam Nally #JimmyScopes JimmyScopes.com from Jimmy Moore on Vimeo.

Today’s Periscope with Jimmy was a teaser for what is to come. I will be joining Jimmy Moore to create a new weekly podcast to address “Keto Questions” you may have. Stay tuned for more information . . .

Fructose and High Triglycerides Lead to Leptin Resistance

I can’t help myself.  Some days I enjoy a good murder mystery, but on others, I enjoy a good journal article elucidating our understanding of leptin.  No, leptin is not a tiny Irish folk character or even a superhero. Leptin is a hormone.  It’s made by fat cells. Anything made by fat cells becomes fascinating to a “fat doctor.”

Why is learning about leptin illuminating?

Well, if Sir Arthur Conan Doyle was an Obesity Specialist, the mystery would have been that Mr. Plump was killed by the wrench in the kitchen, but the wrench seems to have never left tool case in the garage.  No one has been able to figure out how leptin, the allegorical wrench, plays its roll in lepin resistance.  We know that a lack of leptin allows hunger to persist and a person without leptin will continue to eat without the sensation of feeling full – leading to obesity.  What we haven’t understood is – what causes the brain to no longer sense larger and larger amounts of leptin being produced by those who are obese.

That is . . . we haven’t understood it until now. . .

We have known for some time that the hormone leptin is a key hormone produced by the adipose (fat) cells that suppresses hunger.  A majority of obese patients in my clinic have elevated circulating leptin levels 2-10 times the normal levels. We know that a lack of leptin leads to obesity, but the patients that I see in the office are producing an over abundance consistent with leptin resistance. The leptin signal is not being recognized by the brain.  This is very similar to type II diabetes and insulin resistance. The pancreas is producing an over abundance of insulin, but the cells are recognizing the signal to let the glucose in through the door way.

CNS Neural Pathways

Three recent and very interesting studies have pointed to the probable cause.  First, one of the most common genetic disorders causing human obesity is loss of function of the melanocortin receptor.

Leptin Effect on Hypothalamus
Image adapted from 2011 “The Skinny About Fat” presentation – Adam Nally, D.O.

If the MC-4R receptor is broken, suppression of appetite is limited, continued eating occurs and weight gain continues.  Leptin, produced by every adipose cell in the body, is carried in the blood stream to the brain and must pass through the blood-brain barrier.  Once it crosses the blood-brain barrier and enters the hypothalamus, it has a stimulatory effect on the MC-3R receptor in the Arcuate Nucleus of the hypothalamus causing stimulation of the MC-4R receptor in the Parventricular Nucleus and Lateral Hypothalamus to turn off hunger.

Most Common Obesity Genetic Disorder
Image adapted from 2011 “The Skinny About Fat” presentation – Adam Nally, D.O.

However, if leptin cannot cross the blood brain barrier, the signal is never received from the adipose cells and continued eating without satiation (feeling full) persists.  Studies have shown that dietary fructose ingestion alone or in combination with diets high in fat suppress the transmission of leptin across the blood-brain barrier.

Leptin resistance causes
Image adapted from 2011 “The Skinny About Fat” presentation – Adam Nally, D.O.

Fructose is the primary component of high-fructose corn syrup, and makes up 45-50% of every other type of natural form of sugar (sucrose).  Yes, it’s the major component found in table sugar, brown sugar, honey, agave, molasses and maple syrup.  This is why a Paleolithic Diet isn’t fully effective for people with leptin resistance.

sucrose

Lastly, anything that raises triglycerides inhibits leptin from crossing the blood-brain barrier.

Triglyceride effect on Leptin
Image adapted from 2011 “The Skinny About Fat” presentation – Adam Nally, D.O.

Insulin has a direct effect on triglycerides.  (See the articles “Insulin Resistance & The Horse,” “Fat Thoughts on Cholesterol,” “Ketogenic Living” and “So, What is this Ketogenic Thing?“).  If your insulin levels go up, triglyceride production goes up. The patient with insulin resistance, pre-diabetes, impaired fasting glucose or type II diabetes produces between two to ten times the normal amount of insulin when eating the standard American diet (SAD diet).  These patients have significant triglyceride elevation because of the high insulin response to carbohydrates in their diet.  (Many of them were told by their doctor that “It’s just genetic so take your Lipitor.”)  Statin drugs lower the LDL-C (calculated “bad cholesterol” level), but don’t reduce triglycerides effectively. Inadequate treatment of high triglycerides allows poor blood-brain barrier transmission of leptin and worsening leptin resistance.

In fact, this is the challenge and problem with the “frequent fasting” or “intermittent fasting” fad for weight loss that has been popping up in the blogosphere.  If fasting reaches a state of starvation (which is a very fine line metabolically), it stimulates a stress response . . . causing a spike in cortisol, release of glycogen (a form of sugar), a compensatory release of insulin and a spike in triglycerides.  If you have tried intermittent fasting and you’ve gained weight, you are probably not “fasting,” your probably “starving.” We’ve known for years that triglycerides are elevated in starvation.  This diminishes leptin’s ability to cross the blood-brain barrier and leads to worsening leptin and insulin resistance.

High leptin levels caused by leptin resistance also seems to play a significant role in the development of diabetic retinopathy – damage to the tiny blood vessels at the back of the eye feeding the retina.  Diabetic retinopathy starts insidiously without any symptoms initially and can lead to eventual blindness if not treated.  Leptin seems to upregulate vascular endothelial growth factor (VEGF) which leads to narrowing of the blood vessels called “ischemia.” Chronic ischemia of the retinal vessels leads to damage to the delicate retinal cells of the eye.

So what do you do if you have leptin resistance.  First, eliminate carbohydrates from your diet, especially sugars, high fructose corn syrup and any other form of simple sugar.  This is why I am such a big fan of low carbohydrate, high fat diets.

Second, lower your triglycerides. This is done through decreasing overall insulin loads and is very effectively accomplished with a ketogenic diet. You can find this in my book, The KetoCure.  Some additional great sources are KetoClarity, The Art and Science of Low Carbohydrate Living, and The Ketogenic Cookbook.

Third, use a supplement containing alpha-lipoic acid, carnosine high gamma vitamin E and benfothiamin (derivative of Vitamin B1).  These have been demonstrated to decrease inflammation and render protection to the blood vessels.

The use of Epigallocatechin gallate (EGCg), a derivative extract of green tea, has been shown to repress hepatic glucose production, one of the insidious factors of insulin resistance, and may play a role in stabilizing the effect insulin has on production of triglycerides. You should consider using KetoEssentials. It is my specially formulated multivitamin that contains all of the above supplements, and includes methylated folic acid (B9), the necessary vitamin B6 & B12, chromium, vandium & zinc that help to further stabilize insulin resistance.

Fourth, get a good night’s sleep.  Lack of sleep causes a stress response, increases cortisol, raises blood sugar and insulin leading to further leptin resistance.

Fifth, mild to moderate resistance exercise has been shown for years to improve insulin resistance significantly.  If you’re not exercising, take a 20 minute walk 2-3 times per week, ride a bike for 20 minutes, start a weight lifting program, consider yoga or Pilates,  Remember, jumping to conclusions, flying off the handle, carrying things too far, dodging responsibility and pushing your luck don’t qualify as resistance exercise.

Above all, if you’re having trouble losing weight, controlling insulin or leptin, see your doctor.  He or she can really help.

References:

  1. Ray F. Gariano, Anjali K. Nath, Donald J. D’Amico, Thomas Lee, and M. Rocio Sierra–Honigmann. “Elevation of Vitreous Leptin in Diabetic Retinopathy and Retinal Detachment.” Invest Ophthalmol Vis Sci. 2000;41:3576–3581
  2. Hammes HP, Du X . “Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.” Nat Med. 2003 Mar;9(3):294-9. Epub 2003 Feb 18.
  3. Hipkiss AR, Brownson . “Reaction of carnosine with aged proteins: another protective process?” Ann N Y Acad Sci. 2002 Apr;959:285-94.
  4. Zachary A. Knight, K. Schot Hannan, Matthew L. Greenberg, Jeffrey M. Friedman. “Hyperleptinemia Is Required for the Development of Leptin Resistance.” PLoS ONE 5(6): e11376. doi:10.1371/journal.pone.0011376.
  5. Min-Diane Li. “Leptin and Beyond: An Odyssey to the Central Control of Body Weight.” The Yale Journal of Biology and Medicine. 2011;84(1):1-7.
  6. Eri Suganami, Hitoshi Takagi,Hirokazu Ohashi, Kiyoshi Suzuma, Izumi Suzuma, Hideyasu Oh, Daisuke Watanabe, Tomonari Ojimi, Takayoshi Suganami, Yasushi Fujio, Kazuwa Nakao, Yoshihiro Ogawa and Nagahisa Yoshimura. “Leptin Stimulates Ischemia-Induced Retinal Neovascularization: Possible Role of Vascular Endothelial Growth Factor Expressed in Retinal Endothelial Cells.” Diabetes. September, 2004. vol. 53 no. 9 2443-2448
  7. Joseph R. Vasselli, Philip J. Scarpace, Ruth B. S. Harris, and William A. Banks. “Dietary Components in the Development of Leptin Resistance.” Adv. Nutr. 2013: 4: 164–175.
  8. Joseph R. Vasselli. “Fructose-induced leptin resistance: discovery of an unsuspected form of the phenomenon and its significance.” Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1365-9. doi: 10.1152/ajpregu.90674.2008. Epub 2008 Sep 10.
  9. Waltner-Law ME, Wang XL Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem. 2002 Sep 20;277(38):34933-40. Epub 2002 Jul 12.

Cinnamon Swirl Cheese Cake . . . (I think this will be a desert on the menu in Heaven)

File Sep 30, 12 57 46 PM

While at the house last night, Jimmy Moore, his wife Christine, and my wife Tiffini made this delicious cinnamon swirl cheese cake from The Ketogenic Cookbook.  I think I have a new favorite!!!  I seriously have not had a better cheesecake and this one is lowcarb, gluten free and keeps you in ketosis.  Thank you Jimmy Moore and Maria Emmerich for such a yummy recipe.  (I even had some for breakfast this morning . . . . mmmmm).

If you want a great low carb recipe, pick up a copy of the book and turn to page 336.

Until next time . . .  keep the ketones high!

Jimmy Moore visiting Nally Family Practice . . .

The amazing Jimmy Moore and his wonderful wife, Christine, will be stopping by my office on Monday, September 28th, 2015, between the hours of 9 am and 1pm.  Jimmy Moore, Podcaster for Livin’ La Vita Low Carb and author of The Ketogenic Cookbook, KetoClarity and Cholesterol Clarity has been in Phoenix this weekend and agreed to visit the office.

Cholesterol Clarity KetoClarity Ketogenic Cookbook

Jimmy Moore

I have been recommending his books and website to my patients for years.  His website, books and podcasts have served as superb resources for Low-Carb, High Fat and Paleo dietary programs and patients just starting or fine tuning their programs.

Jimmy and his sweet wife, Christine, have become great friends and trusted colleagues over the years as new science and treatment protocols have been identified in the treatment of obesity, insulin resistance and diabetes. He has been a resource for me and my patients for over 10 years.

Pick up your copy of these books at Barnes & Noble or your favorite nearby bookstore; and if you are in the neighborhood and would like meet Jimmy, bring your copy of the Ketogenic Cookbook, KetoClarity or Cholesterol Clarity to get signed and shake his hand.

If you haven’t checked out his podcasts on Livin’ La Vita Low Carb, or seen his Periscope casts on JimmyScopes.com you need to click on the links and check them out.

The Power of a Good Vitamin

“So, Doc, which vitamin should I take?”

I’ve heard this question at least 5-6 times per day for the last 20 years.  The problem has been, there hasn’t been just one or two products that fit my or my patient’s needs.  I’ve seen many that are close, but no one seems to understand the needed nutrients for insulin resistance, leptin resistance and the tremendous effect adequate nutrients has on inflammation, atherosclerosis, uric acid, sodium balance, cholesterol and blood pressure.  That is, until I found a company that would let me design my own vitamin.

Working with a world renowned lab, I put together what I know to be the best ketogenic multivitamin on the market. I give you the KetoNutritionals Multivitamin.”

It provides the nutrients that we recognize are essential to the TCA (tricarboxylic acid) or Krebs cycle.  I call it the Multivitamin Adult Formula, because it has the potential to enhance the body’s ability to use insulin, leptin and regulate normal blood sugar and maintain ketosis.  Now, it is essential that I inform you that these statements have not been evaluated by the FDA and that this product is not intended to diagnose, treat, cure, or prevent any disease.

Methylated Folic Acid

However, 60-65% of pre-diabetic and diabetic patients I see in the office do not correctly convert Folic Acid (Vitamin B9).  It is suspected that over 40% of the population in general has a genetic deficiency in the gene that codes for MTHFR.  MTHFR (also called methylenetetrahydrofolate reductase) is a genetic sequence that encodes for an essential enzyme in your body that helps make the active form of folate. Your body cannot make folate on its own, so it requires enzymes including the one encoded by the MTHFR gene, to make it from the foods that you eat. MTHFR enzyme also has an important role in making amino acids, the building blocks of proteins, by helping convert the chemical homocysteine to methionine in concert with Vitamin B12. Homocysteine is a harmful chemical made by your body that can damage the lipid membrane of cells leading to damage of the walls of your blood vessels, and may affect your blood clotting. In contrast, methionine is an amino acid required by your body for normal functioning.  Supplementing the methylated folate helps to provide the needed components for methionine production.  KetoNutritional Multivitamin contains both forms of active isomer, naturally occurring folates.  MTHFR deficiency can easily be tested for through a simple saliva test in the office.

MTHFR pathways
Metabolism of folate and homocysteine. American Journal of Physiology – Heart and Circulatory Physiology Published 1 July 2004 Vol. 287 no. 1

The conversion of methionine to SAMe is essential in this pathway. SAMe (pronounced Sammy) is necessary for methylation.  It is essential in the formation of neurotransmitters like serotonin and liver detoxification through the methylation pathway.  Serotonin is key in the treatment and prevention of depression, chronic pain, and liver detoxification.  In a number of cases, just fixing this methylation has dramatically improved symptoms of depression that would have otherwise been treated with strong psychogenic medications.

N-Acytylcysteine

Cysteine is used by the body as a source of sulfur for detoxification and the production of glutathione.  Glutathione is your body’s chief anti-oxidant and protector against all kinds of damage.  This is where Vitamin B6 plays a major role.  Vitamin B6 is also a cofactor in hundreds of different chemical reactions necessary for healthy hormones like estrogen, and progesterone.  It is also essential for the production of neurotransmitters like serotonin, dopamine, and GABA for proper brain function.

Carnosine

KetoEssentials contains the essential vitamins to allow these metabolic pathways to function properly. May people on a ketogenic diet don’t get the full effect of weight loss until adequate Vitamin B12 and Vitamin B6 are supplemented.  It also contains Vitamin B1, and carnosine that have been found to decrease the effect of inflammatory glycation and damage caused by higher blood sugars like diabetic retinopathy.  High gamma Vitamin E has also demonstrated retinopathy protection.

Alpha Lipoic Acid, Taurine, ECGC

Alpha lipoic acid combined with biotin has been shown to augment a more natural, healthy insulin secretion thereby promoting a more effective glucose metabolism.  Taurine, epigallocatechin gallate (EGCg) from green tea and Vitamin D have all been shown to improve the effect of the insulin you produce.

Improving insulin use and production has a direct effect your triglycerides. We now know that when your triglycerides are “out -of-whack,” leptin transport across the blood brain barrier is affected and this worsens your risk leptin resistance.  Leptin is that amazing hormone that tells your brain that your fat cells are “full” and to stop eating.

Vitamin A

Vitamin A as a carotenoid acts helps aid immune function and Molybdenum aids in detoxification processes in the body.

Zinc

Added zinc, taurine and EGCg to reduce the damaging effects that fructose can have in the liver, and also enhancing your insulin signaling. Added zinc also helps stabilize your testosterone and sex hormones.

Chromium, Manganese, Vanadium

But, these vitamins and anti-oxidants don’t help if they’re not absorbed correctly, so magnesium, chromium, zinc, manganese and vanadium help to enhance absorption. Correct supplementation of these nutrients may have the effect of normalizing glucose, insulin and leptin levels an reduction in risk for long term cardiovascular disease, diabetic complications, water retention, and more effective weight loss.

#KetoEssentialsIngredients #KetonianKing #DocMuscles

 

 

 

KetoNutritional Multivitamin 

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References:

  1. Moat SJ, Doshi SN, Lang D, McDowell IFW, Lewis MJ, Goodfellow J.  “Treatment of coronary heart disease with folic acid: is there a future?” American Journal of Physiology – Heart and Circulatory Physiology Published 1 July 2004 Vol. 287 no. 1, H1-H7 DOI: 10.1152/ajpheart.00952.2003

  2. Hipkiss AR, Brownson . Reaction of carnosine with aged proteins: another protective process? Ann N Y Acad Sci. 2002 Apr;959:285-94.

  3. Waltner-Law ME, Wang XL Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem. 2002 Sep 20;277(38):34933-40. Epub 2002 Jul 12.

  4. Jacob S, Ruus P, Hermann R, Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled trial. Free Radic Biol Med. 1999 Aug;27(3-4):309-14.

  5. Boucher BJ . Inadequate vitamin D status: does it contribute to the disorders comprising syndrome ‘X’? Br J Nutr. 1998 Apr;79(4):315-27.

  6. Hammes HP, Du X . Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003 Mar;9(3):294-9. Epub 2003 Feb 18.

  7. Maassen JA, Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology? Panminerva Med. 2002 Dec;44(4):295-300.

  8. Ozcelikay AT, Becker DJ. Improvement of glucose and lipid metabolism in diabetic rats treated with molybdate. Am J Physiol. 1996 Feb;270(2 Pt 1):E344-52.
  9. Banks WA, Coon AB, Robinson SM, Moinuddin A, Schultz JM, Nakaoke R, Morley JE. Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier. Diabetes May 2004 vol. 53 no. 5 1253-1260. 

Looking to be De-Inked?

Do you have that tattoo you’d like to get rid of?  Like many with an unwanted or unattractive Tattoo, Victoria Beckham and Andrea Catherwood aren’t so happy with their’s (See the article in the Telegraph).

AndreaCatherwoodTattoo
Andrea Catherwood would prefer her tattoo wasn’t there . . . Sept 22, 2015 – The Telegraph (http://www.telegraph.co.uk/women/womens-life/11882831/Like-Victoria-Beckham-I-want-rid-of-my-tattoo.html)

Come see us and we’ll tell you about the world’s fastest tattoo removal laser, the PicoSure.

Homemade Rootbeer – Ketosis Style!!

ery October I get a hankering for homemade root beer.  But it is usually loaded with sugar.  Thanks to Maria Emmerich and her amazing recipes, that doesn’t have to happen this year.   She just posted this on her site today and I can’t wait to try this as I sit by my fire pit roasting some hot dogs with my kids . . . Thanks Maria.

I pasted a copy of her root beer image below just to make you drool, too  . . .

Homemade Rootbeer - Low Carb

Link on the recipe at her site HERE.

(Another great use for the SodaStream as well . . . the day just keeps getting better!)

The Dreaded Seven . . . (Seven Detrimental Things Caused by High Insulin Loads)

85% of the people that walk through my office doors have some degree of insulin resistance.

What is “insulin resistance?”  It is an over production of insulin in response to ANY form of carbohydrate intake (yes, even the “good carbs” cause an insulin over-response in a person with insulin resistance.)

How do I know this? Because I routinely check insulin levels (I check them every three months) and the down stream markers of insulin on a large number of the patients that I see.  I have been fascinated by the fact that a diet high in both sugar and fat [like the Standard American Diet, (SAD) diet]  turn on the genetics leading to insulin resistance.  Starch and sugar load the genetic gun.

Insulin acts like a key at the glucose doorway of every cell in your body.  In many people, the insulin signal is blocked by hormones produced in the fat cell and the the insulin, acting like a “dull or worn out key” – can’t open the glucose doorway as efficiently.

So, the body panics, and releases extra insulin in response to the same load of carbohydrate or glucose.  People with insulin resistance will produce between 2-20 times the normal amount of insulin in response to a simple carbohydrate load.  Recent studies(1, 2) reveal high cholesterol and diets high in both fat and carbohydrate cause insulin resistance to progress or worsen.

So, instead of producing enough insulin to accommodate the one slice of bread or the one apple that you might eat, the insulin resistant person produces enough insulin for an entire loaf of bread or an entire bushel of apples.  This excess insulin then stimulates one or all of the following:

  1. Weight Gain – Insulin directly stimulates weight gain by activating lipoprotein lipase to take up triglycerides into the fat cells.  This causes direct storage of fat and increases your waistline. (3)  weight tape measure
  2. Elevated Triglycerides – Insulin directly stimulates production of free fatty acids and triglycerides through hepatic gluconeogenesis and is even more notably amplified by the broken signaling mechanism of the FOX-01 phosphorylation mechanism in patients with insulin resistance. (4)triglycerides homer simpson
  3. Increased number of Small Dense LDL (sdLDL) particles – Low density lipoprotein (LDL, or “bad cholesterol”) is actually comprised of various sized lipoproteins including small, medium and large.  As triglycerides increase, the small dense LDL particle numbers increase.  Research points to the fact that it is the small dense particle that is highly atherogenic (leading to the formation of vascular plaques within the arteries). (5, 8)
  4. Elevated Uric Acid – Leptin resistance and insulin resistance syndromes are often found together and are suspected to have significant influence on each other.  High insulin loads lead to “sick adipose cells” causing leptin resistance.  This has a dramatic effect on hepatic fructose metabolism increasing the production of uric acid.  Excess insulin suppresses urinary excretion of uric acid and dramatically increases serum content of uric acid and the risk of kidney stones and gout. (6, 7)gout-pain
  5. Increased Inflammation – Increased levels of circulating insulin have a direct correlation on raising many of the inflammatory markers and hormones including TNF-alpha and IL-6 in the body (9).  Any disease process that is caused by chronic inflammation can be amplified by increased circulating levels of insulin including asthma, acne, eczema, psoriasis, arthritis, inflammatory bowel and celiac disease, etc.
  6. Elevated Blood Pressure – Increased uric acid production from insulin resistance as noted above directly suppresses production of nitric oxide within the vasculature and increases blood pressure (7). This completes the triad of metabolic syndrome (elevated triglycerides & cholesterol, weight gain, and elevated blood pressure) found in patients with insulin resistance.Blood-pressure
  7. Water Retention – We have known for many years that insulin affects the way the kidney uses sodium in the distal nephron.  Insulin has a direct effect on sodium retention in the kidney.  As insulin levels rise, the kidney retains increased levels of sodium (10).  Water follows sodium and thereby causes fluid retention.  This is the reason that many of my insulin resistant patients who have struggled with leg swelling and edema suddenly improve when they correct their diet and their high circulating insulin levels fall.  It is also the reason that many of my patients show up in my office after the holidays with swollen legs and amplified swelling in their varicose veins after cheating on their ketogenic diets.

swollen feet

If you are plagued by any or all of these, my first suggestion is to see your doctor and get screened for insulin resistance.  I treat patients with these every day and have reversed these effects in thousands of patients with the correct diet and/or medications.  Having seen these signs and patterns over the last 20 years of medical practice, I am still astonished every day by the dramatic effect our diet plays on the hormonal changes within the body. Remember that the food you eat is actually the most powerful form of medicine . . . and the slowest form of pernicious poison.

A ketogenic or carnivorous diet is your first step.

We take most insurances, however, check out my concierge program or my Direct Primary Care program if you are interested in an alternative to insurance.

References:

  1. Cholesterol Elevation Impairs Glucose-Stimulated Ca2+Signaling in Mouse Pancreatic β-Cells, Endocrinology, June 2011, Andy K. Lee, Valerie Yeung-Yam-Wah, Frederick W. Tse, and Amy Tse; DOI: http://dx.doi.org/10.1210/en.2011-0124
  2. Glucose-Stimulated Upregulation of GLUT2 Gene Is Mediated by Sterol Response Element–Binding Protein-1c in the Hepatocytes, DIABETES, VOL. 54, JUNE 2005; Seung-Soon Im, Seung-Youn Kang, So-Youn Kim, Ha-il Kim, Jae-Woo Kim, Kyung-Sup Kim and Yong-Ho Ahn
  3. Obesity and Insulin Resistance. J Clin Invest. 2000 Aug;106(4):473-81.Kahn BB, Flier JS
  4. Selective versus Total Insulin Resistance: A Pathogenic Paradox, Cell Metabolism, Volume 7, Issue 2, 6 February 2008, Pages 95–96, Michael S. Brown, Joseph L. Goldstein
  5. Association between small dense LDL and early atherosclerosis in a sample of menopausal women, Department of Clinical Medicine and Surgery, University “Federico II” Medical School, Naples, Italy Division of Cardiology, Moscati Hospital, Aversa, Italy A. Cardarelli Hospital, Naples, Italy, Gentile M, Panico S, et al., Clinica Chimica Acta, 2013
  6. Sugar, Uric Acid and the Etiology of Diabetes and Obesity. Diabetes. 2013;62(10):3307-3315, Richard J. Johnson; Takahiko Nakagawa; L. Gabriela Sanchez-Lozada; Mohamed Shafiu; Shikha Sundaram; Myphuong Le; Takuji Ishimoto; Yuri Y. Sautin; Miguel A. Lanaspa
  7. Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc. 2010 Sep;110(9):1307-21. doi: 10.1016/j.jada.2010.06.008. Lustig RH
  8. Cardiovascular Risk in Patients Achieving Low-Density Lipoprotein Cholesterol and Particle Targets. Atherosclerosis. Vol 235; 585-591, May 2014, Peter P. Toth, Michael Grabner, Rajeshwari S. Punekar, Ralph A. QuimboMark J. Cziraky c, Terry A. Jacobson
  9. Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome The Insulin Resistance Atherosclerosis Study (IRAS), Circulation, July 2000, 102:42-47; Andreas Festa, MD; Ralph D’Agostino, Jr, PhD; George Howard, DrPH; Leena Mykka¨nen, MD, PhD; Russell P. Tracy, PhD; Steven M. Haffner, MD
  10. The Effect of Insulin on Renal Sodium Metabolism. Diabetologia. September 1981, Volume 21, Issue 3, pp 165-171. R. A. DeFronzo

Snack Time . . . Bacon Chips & Guacamole!!

To maintain ketosis, the key is keeping the fat content high and the carb content low  . . .while moderating the protein intake.  Unless you are running triathalon’s, body building daily or exercising more than 45 minutes daily, most women don’t need more than 70-80 grams of protein per day.  Most men don’t need more than 80-90 grams per day.

Now, stop looking at your phone and go make some bacon chips . . . 🙂

Does Sharpening the Pencil Sharpen the Mind . . . ?

Einstien Schooling

As our children return to school this year and the pencils are sharpened, our questions should focus on whether the minds of our youth being sharpened.  If not, then do something about it.

For over 50 years we accepted the indoctrination of rote fact about the calorie-in/calorie-out dogma of weight gain.  The consequence of learning rather than thinking is of the diseases of civilization now prevalent in over 2/3rds of the population.

Handy Charts for Maintaining Ketosis

I found these charts to be very helpful when trying to calculate your fat intake with a meal.  Fish can be challenging in calculating fat content.  After reading these charts, I’m craving some sashimi’ed mackerel and salmon.Cuts of Beef for Ketosis

Fish Keto Chart

Great charts like these can be found at http://mariamindbodyhealth.com/charts/

Enjoy!!

My Copy of The Ketogenic Cookbook Arrived!!!!

Look what I just got in the mail this afternoon. . . my copy of Jimmy Moore & Maria Emmerich’s The Ketogenic Cookbook

Wow. Great info, fantastic recipes (with amazing pictures, by the way!) and the most up to date ketogenic advise out there.  I’m impressed.

Picture 2

What a fantastic addition to my library.  I was going snap a few shots of my favorite dishes in it, but my wife picked it up while I was typing and won’t put it down. . . .

Thanks, Jimmy Moore’s Livn’ La Vida Low-Carb & Maria’s Mind Body Health!!

Bariatric Surgery vs Dietary Weight Loss

A recent study, published in JAMA Surgery, this week compares the three-year outcomes of bariatric surgery versus lifestyle intervention for type II diabetics.  This particular study made the headlines of the Wall Street Journal because the outcomes revealed “Weight-Loss Surgery Better Than Diet and Exercise in Treating Type 2 Diabetes…”

Really?!  That is news to me, a baratrician that’s been treating type II diabetes for over 15 years!   This simple three year study in 62 patient contradicts what I’ve seen in my office for 15 years. This study and the media-hype associated with it are a serious problem.  Why? Because the study was based on a flawed design.

We all know that baratric surgery has significant weight loss as a result.  And, we all know that most of those patients with diabetes have significant improvement in their diabetes at the 2-5 year mark (what happens after 5 years is a completely different story).   But why compare that to a poorly designed lifestyle protocol that failed to show successful weight loss?  Yes, poorly designed.

obese-weightThis study was based on protocols from the Diabetes Prevention Program and the Look AHEAD trial, both of which were very large trials restricting calories, fat and increasing exercise.  Both of these trials failed to show any significant weight loss and failed to produce any significant reduction in overall mortality.  Why?  Because both trials used the wrong dietary approach. We’ve know for years, as was emphasized by the Women’s Health  Initiative study as well, that caloric restriction combined with exercise doesn’t reduce body weight in the long run by more than 1%.  So the bariatric surgeons in the study above compare a known effective treatment to a known ineffective treatment?  And, it gets Wall Street Journal Headlines.   It’s a sad day for medicine.  And an even sadder day for the treatment of obesity.

Is no one listening?  Weight loss is not a question of thermodynamics – it is not the calorie in / calorie out dogma we’ve been brainwashed into believing over the last 50 years.  Weight loss is hormonal.  The study published in JAMA Surgery this week proves that.  Baratric surgery effects grelin and the forced dietary changes reduce insulin (patients receive what equates to a low carbohydrate diet post bypass surgery).  Both of which have significant effect on weight gain and loss.  Caloric restriction and exercise affect neither of these.

Carbohydrate restriction, on the other hand affects insulin dramatically.  Carbohydrate restriction turns off the tremendous excess insulin hormonal response that occurs in up to 85% of the patient’s I see in my office.  Call me when the bariatric surgeons actually compare bariatric surgery to a true ketogenic diet.

So, What is this Ketogenic Thing Again . . . ?

I’ve personally been following and prescribing ketogenic diets to my patients since 2005.   When I started on my ketogenic journey, it was called a “Low Carbohydrate Diet.” Over the last 5-10 years, we’ve learned a thing or two about how the body processes carbohydrate, protein and fat. Specifically, it’s not just the restriction of the carbohydrates that leads to metabolic health, but appropriate protein intake and significant emphasis on the level and type of fat intake as well. The majority of people who cut out carbohydrates will initially see successful weight loss, but to maintain that weight loss and see significant metabolic changes that reverse the diseases of civilization, an understanding of protein and fat needs are essential.

It’s Not Necessarily a High Protein Diet

Most people, when they hear you’re following a “Low-Carb” diet . . . respond with, “Oh, you are on that high protein, Adkins’ thing, . . . right?!”

Bacon Recipes

Well, not really. A true ketogenic diet is NOT a “high protein diet.” However, you must be ingesting enough protein to maintain muscle, hair growth and energy levels.  Most people, having been brainwashed in grade school and middle school about the horrors of fat in the diet, assume that if you’re not eating carbohydrates, then you must be eating extra protein to stay satiated.  (No one would ever intentionally increase the fat in their diet, right?!!)  However, remember that protein and fat usually come together in the sources that the Good Lord put them in.

That’s the impression that most people in my office get when I mention the words “Low-Carb” or “Adkins.”  And, before I have a chance to explain that I’m not recommending that you race home to eat three large turkey legs and a pound of turkey bacon, the vegetarians gather their things to leave and the former home economics teachers begin to get chest pain at the mental picture in their heads.

How Are Ketones Made?

A ketogenic diet is one which allows your body to use ketones as it’s primary fuel source. Ketones are produced from the breakdown of triglyceride and free fatty acids.  Ketones are essentially produced by two distinctly different events:

1) Starvation caused by prolonged periods without food (which is essentially what happens to type I diabetics when they have no insulin at all in their systems)

2) When fat is ingested as the primary fuel, and very low levels of insulin are  concurrently produced, primarily when the diet has minimal to no carbohydrate present (allowing the body to activate its free fatty acid reserves found within in the adipose cells).

The body is an amazing machine.  It was designed to take any of the three main macro-nutrients (carbohydrate, protein or fat) as fuel and function quite well.  It’s like a futuristic car that can run on unleaded gasoline, oil, or diesel fuel.  It is able to recognize which fuel is present and run quite well off of any of the three.  The amazing thing about the body is that we mix up all three fuel types and just pour them into the tank.  Impressively, the body can separate them out and run very well in the short term on any combination of mixes.  We don’t have cars or trucks that do that today . . . maybe in the future . . .?

We have Two Fuel Systems

I like to equate carbohydrates to unleaded fuel. These are clean burning, easy to access and cheap.  However, the body requires the production of insulin to use this “unleaded” type of fuel. When carbohydrates are identified to be present in the liver and pancreas, insulin is released so that the rest of the cells throughout the body can “open the tank” and let the carbohydrate into the cell to be used as fuel.  The challenge is that carbohydrates don’t store very well in the form they are supplied in, so, as a protective mechanism against starvation and famine, if excess carbohydrate is found in the system, it is converted into triglyceride.  Insulin is required for this.  Interestingly, when your insulin levels rise, the signal to the body is that “unleaded fuel” is in the system, so it stores any fats and excess carbohydrates in the form of free fatty acid and triglyceride.  Carbohydrate stimulate an insulin response and cause fat storage.  It is the same reason we give corn to cattle — to plump them up before taking them to market.

Fat then is the “diesel fuel” of macro-nutrients.  It burns well, can be stored very easily, and provides over twice the energy to the body when measured in the form of k-cal per gram.  Fat is used preferentially when there is limited or no insulin floating around the blood stream and is quickly and efficiency stored when other forms of fuel are available.  (Insulin being the key hormone signaling that other fuel is around.)

Nutritional Ketosis is Using Fat as Your Optimum Fuel

So what is this “ketosis thing?” It is a method of dietary change (a lifestyle) that intentionally focuses the body’s metabolism to use fat (in the form of triglyceride & free fatty acid) as its primary fuel. Leading to weight loss, dramatically improved blood sugars, significantly improved cholesterol and triglyceride levels, and notably improved inflammatory markers.

“But don’t you end up eating a lot more protein on your weight loss program?” I frequently get asked.

Honestly, No.

Protein and fat are both very filling, and most people find that limiting the carbohydrates actually causes less hunger and diminishes the rebound carbohydrate cravings often stimulated by the two or three slices of bread, pasta or that potato often occurring 2-3 hours later. Interestingly, most people don’t eat that much more and the protein levels remain fairly constant.  Because fat and protein come together in meats, eggs, fish, etc., satiation occurs with just minor increases in dietary intake real animal food.  I don’t recommend increase the fat alone.  I recommend increasing the amount of real animal protein until you are full.  This is even more satiating and many people find themselves eating only twice a day when they are hungry.

 Excessive protein in those who are morbidly obese with severe overproduction of insulin can experience a spike the insulin levels further with large amounts of protein. Protein can be equated to the oil you put in your car.  Protein is a building block used for muscle, connective tissue and some essential metabolic functions.  When too much protein, in this group is ingested, it spikes the insulin. (See my article on Why Your Chicken Salad is Making you Fat)

Most people have problems when they start supplementing with protein shakes.  These often contain sweeteners that raise insulin and consequently halts your weight loss – or even causing weight gain.