{"id":1336,"date":"2015-11-22T21:04:46","date_gmt":"2015-11-23T04:04:46","guid":{"rendered":"http:\/\/docmuscles.com\/?p=1336"},"modified":"2018-04-20T13:00:20","modified_gmt":"2018-04-20T13:00:20","slug":"the-ketogenic-antidote-to-chronic-renal-disease","status":"publish","type":"post","link":"https:\/\/www.docmuscles.com\/the-ketogenic-antidote-to-chronic-renal-disease\/","title":{"rendered":"The Ketogenic Antidote to Chronic Renal Disease"},"content":{"rendered":"<p>It is well know that one of the most profound complications of diabetes is damage to the kidney and the very small arteries within the kidney acting as your body’s filtration system. \u00a0The kidney\u00a0begins to lose the ability to adequately filter and retain microscopic protein progressively over time. As the blood sugar and insulin levels continually\u00a0rise over time in the patient with diabetes or pre-diabetes, damage to the delicate filtering system of the kidneys occur. This very\u00a0common and progressively damaging problem is called \u201cnephropathy.\u201d<\/p>\n<figure id=\"attachment_73\" aria-describedby=\"caption-attachment-73\" style=\"width: 420px\" class=\"wp-caption alignnone\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-73\" src=\"https:\/\/docmuscles.files.wordpress.com\/2014\/05\/nephropathy-kidney.png?resize=420%2C423\" alt=\"nephropathy kidney\" width=\"420\" height=\"423\" \/><figcaption id=\"caption-attachment-73\" class=\"wp-caption-text\">Chronic elevated blood sugar and insulin cause the filtering system to become more and more “leaky” and ineffective.<\/figcaption><\/figure>\n<p>We knew in 1972 that patients with diabetes had thickening of the <em>basement membrane<\/em> or <em>endothelium<\/em> of the small tubles within the kidneys. \u00a0In fact, 98.6% of diabetics tested had thickening of this area of endothelium and tubules also called the renal glomeruli (1). \u00a0This allows the glomerulus or filtration system of the kidney to become more “leaky” and microscopic protein loss begins to occur through the kidney. \u00a0This loss of important proteins in the blood is called “albuminuria” or “micro-albuminuria.” \u00a0It is a flag that further damage of the kidney can and will occur without making significant changes to lower the blood sugar and the insulin. As of today, it is not totally clear how the basement membrane is damaged at the microscopic level, however, there is some evidence that elevated insulin has both a physical and immune type effect that stimulates oxidative stress, atherogenesis, immunoglobulins, as well as the formation advanced glycation end products leading to endothelial wall damage (2).<\/p>\n<p>Recent research reveals that a ketogenic diet effectively repairs and\/or completely reverses the albuminuria (3).<\/p>\n<p>Evidence in my office of the significant improvement in micro-albumin can be seen in the one of a number of case studies below:<\/p>\n<h6 style=\"padding-left: 30px;\">72 year old male with history of diabetes, diabetic nephropathy already treated with full dose statins, ACE inhibtors, metformin, and Januvia. \u00a0(Remember, microalbumin should be <30 mg\/g)<\/h6>\n<h6 style=\"padding-left: 30px;\"><span style=\"text-decoration: underline;\"><strong>Date \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Microalbumin \u00a0 \u00a0 \u00a0HbA1c<\/strong><\/span><\/h6>\n<h6 style=\"padding-left: 30px;\">8\/12\/2010 \u00a0 \u00a0 \u00a0 \u00a02264 mg\/g \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a06.4% \u00a0 Started carb restriction <30 g per day.<\/h6>\n<h6 style=\"padding-left: 30px;\">10\/01\/2010 \u00a0 \u00a0 \u00a0 \u00a01274 mg\/g \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 5.2%<\/h6>\n<h6 style=\"padding-left: 30px;\">1\/08\/2011 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a01198 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a05.8% \u00a0 Admits to cheating over holidays<\/h6>\n<h6 style=\"padding-left: 30px;\">12\/26\/2013 \u00a0 \u00a0 \u00a0 \u00a0 2434 mg\/g \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a06.8% \u00a0 Returned from 2 yr travel-off diet<\/h6>\n<h6 style=\"padding-left: 30px;\">2\/27\/2014 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0399 mg\/g \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 6.3% \u00a0Restarted carb restriction <20g per day<\/h6>\n<h6 style=\"padding-left: 30px;\">6\/20\/2014 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 190 mg\/g \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a07.0% \u00a0Traveling – no carb restriction<\/h6>\n<h6 style=\"padding-left: 30px;\">10\/31\/2014 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0280 mg\/g \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a06.9% \u00a0Partial carb restriction <10 g\/meal<\/h6>\n<h6 style=\"padding-left: 30px;\">3\/14\/2015 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a097 mg\/g \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a06.8%<\/h6>\n<p>The patient began following a ketogenic diet in 2010. \u00a0After improvement he moved out of town for two years and “fell of the wagon.” Upon returning h restarted his carbohydrate diet and was only partially following it. \u00a0As you can see, he also admitted to some cheating on the carbohydrate restriction over the holidays. \u00a0In light of this, carbohydrate restriction decreased his albuminuria from 2400 to 97 mg\/g within a period of 18 months.<\/p>\n<p>References:<\/p>\n<ol>\n<li>Siperstein MS, Unger RH, Madison LL. “Further Electron Microscopic Studies of Diabetic Microagniopathy.” <em>Early Diabetes: Advances in Metabolic Disorders, sup 1.<\/em> New York: Academic Press, 1972, p261-271.<\/li>\n<li>\n<div class=\"abstractRow\">\n<div class=\"label\">Nasr SH, D’Agati VD. \u00a0“Nodular glomerulosclerosis in the nondiabetic smoker.” \u00a0J Am Soc Nephrol. 2007;18(7):2032.<\/div>\n<\/div>\n<div class=\"abstractRow\"><\/div>\n<\/li>\n<li>Poplawski MM, Mastaitis JW, Isoda F, Grosjean F, Zheng F, Mobbs CV (2011) Reversal of Diabetic Nephropathy by a Ketogenic Diet. PLoS ONE 6(4): e18604. doi:10.1371\/journal.pone.0018604<\/li>\n<\/ol>\n<span class=\"inf_infusionsoft_bottom_trigger\"><\/span>","protected":false},"excerpt":{"rendered":"<p>It is well know that one of the most profound complications of diabetes is damage to the kidney and the very small arteries within the kidney acting as your body’s filtration system. \u00a0The kidney\u00a0begins to lose the ability to adequately filter and retain microscopic protein progressively over time. As the blood sugar and insulin levels …<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[41,946,4,315,232,356,283,952,1],"tags":[45,918,29,3,6,917,35,8,36],"class_list":["post-1336","post","type-post","status-publish","format-standard","hentry","category-diabetes","category-diabetic","category-health","category-ketoenhance","category-ketogenic-diet","category-ketogenic-lifestyle","category-ketosis","category-kidney","category-uncategorized","tag-carbohydrate-restriction","tag-chronic-renal-disease","tag-diabetes","tag-diet","tag-ketogenic","tag-ketogenic-antidote","tag-ketogenic-diet","tag-low-carb","tag-low-carb-diet"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Ketogenic Antidote to Chronic Renal Disease - DocMuscles<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.docmuscles.com\/the-ketogenic-antidote-to-chronic-renal-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Ketogenic Antidote to Chronic Renal Disease - DocMuscles\" \/>\n<meta property=\"og:description\" content=\"It is well know that one of the most profound complications of diabetes is damage to the kidney and the very small arteries within the kidney acting as your body’s filtration system. \u00a0The kidney\u00a0begins to lose the ability to adequately filter and retain microscopic protein progressively over time. 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